Chemistry:Velufenacin
From HandWiki
Short description: Chemical compound
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| Other names | DA-8010 |
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| Formula | C19H20ClFN2O2 |
| Molar mass | 362.83 g·mol−1 |
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Velufenacin (DA-8010) is a muscarinic antagonist that operates on the M3 receptor and is tissue-selective for bladder over salivary glands. It is in development as a treatment for overactive bladder.[1][2][3][4]
References
- ↑ Son, Hee Seo; Oh, Cheol Young; Choo, Myung-Soo; Kim, Hyeong Gon; Kim, Joon Chul; Lee, Kyu-Sung; Shin, Dong Gil; Cho, Sung Yong et al. (June 2022). "Efficacy and Safety of DA-8010, a Novel M3 Antagonist, in Patients With Overactive Bladder: A Randomized, Double-Blind Phase 2 Study". International Neurourology Journal 26 (2): 119–128. doi:10.5213/inj.2142382.191. ISSN 2093-4777. PMID 35793990.
- ↑ Lee, Min Jung; Moon, Jun-Hwan; Lee, Hyung Keun; Cho, Chong Hwan; Choi, Sung Hak; Im, Weon-Bin (January 2019). "Pharmacological characterization of DA-8010, a novel muscarinic receptor antagonist selective for urinary bladder over salivary gland". European Journal of Pharmacology 843: 240–250. doi:10.1016/j.ejphar.2018.11.037. PMID 30502343.
- ↑ Lee, Dae Young; Lee, Min Jung; Ryu, Chaelim; Lee, Heewon; Brooks, Ashley (February 2023). "Safety, tolerability, and pharmacokinetics of single and multiple ascending Oral doses of DA ‐8010 in healthy subjects: First‐in‐human phase I study". Pharmacology Research & Perspectives 11 (1): e01040. doi:10.1002/prp2.1040. PMID 36734627.
- ↑ Choi, Jin Bong; Jeon, Seung Hwan; Kwon, Eun Bi; Bae, Woong Jin; Cho, Hyuk Jin; Ha, U-Syn; Hong, Sung-Hoo; Lee, Ji Youl et al. (December 2020). "The effects of oral administration of the novel muscarinic receptor antagonist DA-8010 on overactive bladder in rat with bladder outlet obstruction". BMC Urology 20 (1): 41. doi:10.1186/s12894-020-00611-8. PMID 32303205.
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