Biology:N-acylglucosamine-6-phosphate 2-epimerase
| N-acylglucosamine-6-phosphate 2-epimerase | |||||||||
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| Identifiers | |||||||||
| EC number | 5.1.3.9 | ||||||||
| CAS number | 37318-35-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a N-acylglucosamine-6-phosphate 2-epimerase (EC 5.1.3.9) is an enzyme that catalyzes the chemical reaction
- N-acyl-D-glucosamine 6-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] N-acyl-D-mannosamine 6-phosphate
Hence, this enzyme has one substrate, N-acyl-D-glucosamine 6-phosphate, and one product, N-acyl-D-mannosamine 6-phosphate.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine-6-phosphate 2-epimerase. Other names in common use include acylglucosamine-6-phosphate 2-epimerase, and acylglucosamine phosphate 2-epimerase. This enzyme participates in aminosugars metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1Y0E and 1YXY.
References
- "The Sialic Acids. Iv. N-Acyl--D-Glucosamine 6-Phosphate 2-Epimerase". The Journal of Biological Chemistry 240: 1525–30. April 1965. doi:10.1016/S0021-9258(18)97467-3. PMID 14285487.
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