Biology:PRKAR1B
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
cAMP-dependent protein kinase type I-beta regulatory subunit is an enzyme that in humans is encoded by the PRKAR1B gene.[1][2][3]
Clinical significance
Mutations in PRKAR1B cause neurodegenerative disorder.[4]
Interactions
PRKAR1B has been shown to interact with AKAP1[5] and PRKAR1A.[5][6]
References
- ↑ "Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7". Genomics 14 (1): 63–9. Dec 1992. doi:10.1016/S0888-7543(05)80284-8. PMID 1358799.
- ↑ "Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis". Am J Hum Genet 41 (5): 925–32. Dec 1987. PMID 3479018.
- ↑ "Entrez Gene: PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5575.
- ↑ "PRKAR1B mutation associated with a new neurodegenerative disorder with unique pathology". Brain 137 (Pt 5): 1361–73. 2014. doi:10.1093/brain/awu067. PMID 24722252.
- ↑ 5.0 5.1 "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. Mar 2003. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
- ↑ "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. Oct 1993. doi:10.1016/S0021-9258(19)36921-2. PMID 8407966.
Further reading
- "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets 7 (12): 1595–606. 2007. doi:10.2174/138945006779025338. PMID 17168834.
- "Molecular cloning, cDNA structure and tissue-specific expression of the human regulatory subunit RI beta of cAMP-dependent protein kinases". Biochem. Biophys. Res. Commun. 176 (1): 166–72. 1991. doi:10.1016/0006-291X(91)90904-L. PMID 1708242.
- "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. 145 (11): 3699–705. 1991. doi:10.4049/jimmunol.145.11.3699. PMID 1978848.
- "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. 1993. doi:10.1073/pnas.90.14.6676. PMID 7688126. Bibcode: 1993PNAS...90.6676H.
- "Human regulatory subunit RI beta of cAMP-dependent protein kinases: expression, holoenzyme formation and microinjection into living cells". Exp. Cell Res. 214 (2): 595–605. 1994. doi:10.1006/excr.1994.1297. PMID 7925653.
- "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS 8 (7): 1016–7. 1994. doi:10.1097/00002030-199407000-00025. PMID 7946090.
- "Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes". J. Biol. Chem. 268 (28): 21276–83. 1993. doi:10.1016/S0021-9258(19)36921-2. PMID 8407966.
- "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix". J. Virol. 71 (6): 4372–7. 1997. doi:10.1128/JVI.71.6.4372-4377.1997. PMID 9151826.
- "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. 1997. doi:10.1074/jbc.272.36.22385. PMID 9278385.
- "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Res. Hum. Retroviruses 14 (10): 825–33. 1998. doi:10.1089/aid.1998.14.825. PMID 9671211.
- "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation 5 (3–4): 184–92. 1998. doi:10.1159/000026336. PMID 9730685.
- "Diminished levels of protein kinase A RI alpha and RI beta transcripts and proteins in systemic lupus erythematosus T lymphocytes". J. Immunol. 162 (9): 5639–48. 1999. doi:10.4049/jimmunol.162.9.5639. PMID 10228048.
- "The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status". J. Biol. Chem. 277 (25): 22915–24. 2002. doi:10.1074/jbc.M201695200. PMID 11943777.
- "Targeting Protein Phosphatase 1 (PP1) to the Actin Cytoskeleton: the Neurabin I/PP1 Complex Regulates Cell Morphology". Mol. Cell. Biol. 22 (13): 4690–701. 2002. doi:10.1128/MCB.22.13.4690-4701.2002. PMID 12052877.
- "Regulation of the Werner helicase through a direct interaction with a subunit of protein kinase A". FEBS Lett. 521 (1–3): 170–4. 2002. doi:10.1016/S0014-5793(02)02868-5. PMID 12067711.
- "Localization of Triton-insoluble cAMP-dependent kinase type RIbeta in rat and mouse brain". J. Neurocytol. 30 (11): 885–94. 2003. doi:10.1023/A:1020613132648. PMID 12373096.
- "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. 2003. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
External links
- Overview of all the structural information available in the PDB for UniProt: P31321 (Human cAMP-dependent protein kinase type I-beta regulatory subunit) at the PDBe-KB.
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