Biology:AKAP1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.[1][2][3]
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.[3]
Interactions
AKAP1 has been shown to interact with:
References
- ↑ "Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain". Biochem Biophys Res Commun 225 (1): 313–9. Sep 1996. doi:10.1006/bbrc.1996.1172. PMID 8769136.
- ↑ "Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells". J Biol Chem 270 (46): 27804–11. Jan 1996. doi:10.1074/jbc.270.46.27804. PMID 7499250.
- ↑ 3.0 3.1 "Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8165.
- ↑ 4.0 4.1 "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. Nov 2002. doi:10.1074/jbc.M206201200. PMID 12223483.
- ↑ "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. Sep 2001. doi:10.1074/jbc.M103885200. PMID 11483602.
- ↑ 6.0 6.1 "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. Mar 2003. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
- ↑ 7.0 7.1 "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. April 2000. doi:10.1006/jmbi.2000.3662. PMID 10764601.
- ↑ "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes". J. Cell Sci. 112 (16): 2725–36. Aug 1999. doi:10.1242/jcs.112.16.2725. PMID 10413680.
External links
- Human AKAP1 genome location and AKAP1 gene details page in the UCSC Genome Browser.
Further reading
- "Anchoring and scaffold proteins for kinases and phosphatases". Recent Prog. Horm. Res. 52: 409–29; discussion 429–30. 1997. PMID 9238861.
- "AKAP mediated signal transduction". Annu. Rev. Pharmacol. Toxicol. 42: 235–57. 2002. doi:10.1146/annurev.pharmtox.42.083101.135801. PMID 11807172.
- "Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits". J. Biol. Chem. 272 (12): 8057–64. 1997. doi:10.1074/jbc.272.12.8057. PMID 9065479.
- "NH2-Terminal Targeting Motifs Direct Dual Specificity A-Kinase–anchoring Protein 1 (D-AKAP1) to Either Mitochondria or Endoplasmic Reticulum". J. Cell Biol. 145 (5): 951–9. 1999. doi:10.1083/jcb.145.5.951. PMID 10352013.
- "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. 2000. doi:10.1006/jmbi.2000.3662. PMID 10764601.
- "Recruitment of Protein Phosphatase 1 to the Nuclear Envelope by a-Kinase Anchoring Protein Akap149 Is a Prerequisite for Nuclear Lamina Assembly". J. Cell Biol. 150 (6): 1251–62. 2000. doi:10.1083/jcb.150.6.1251. PMID 10995432.
- "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. 2001. doi:10.1074/jbc.M103885200. PMID 11483602.
- "Two distinct caveolin-1 domains mediate the functional interaction of caveolin-1 with protein kinase A". Am. J. Physiol., Cell Physiol. 281 (4): C1241–50. 2001. doi:10.1152/ajpcell.2001.281.4.C1241. PMID 11546661.
- "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. 2003. doi:10.1074/jbc.M206201200. PMID 12223483.
- "AMY-1 interacts with S-AKAP84 and AKAP95 in the cytoplasm and the nucleus, respectively, and inhibits cAMP-dependent protein kinase activity by preventing binding of its catalytic subunit to A-kinase-anchoring protein (AKAP) complex". J. Biol. Chem. 277 (52): 50885–92. 2003. doi:10.1074/jbc.M206387200. PMID 12414807.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. 2003. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056.
- "AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase". J. Cell Sci. 116 (Pt 11): 2237–46. 2004. doi:10.1242/jcs.00432. PMID 12697839.
- "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- "Mitochondrial AKAP121 Binds and Targets Protein Tyrosine Phosphatase D1, a Novel Positive Regulator of src Signaling". Mol. Cell. Biol. 24 (11): 4613–26. 2004. doi:10.1128/MCB.24.11.4613-4626.2004. PMID 15143158.
- "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. 2004. doi:10.1073/pnas.0404720101. PMID 15302935. Bibcode: 2004PNAS..10112130B.
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