Biology:AKAP1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

A kinase anchor protein 1, mitochondrial is an enzyme that in humans is encoded by the AKAP1 gene.[1][2][3]

Function

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.[3]

Interactions

AKAP1 has been shown to interact with:


References

  1. "Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain". Biochem Biophys Res Commun 225 (1): 313–9. Sep 1996. doi:10.1006/bbrc.1996.1172. PMID 8769136. 
  2. "Characterization of S-AKAP84, a novel developmentally regulated A kinase anchor protein of male germ cells". J Biol Chem 270 (46): 27804–11. Jan 1996. doi:10.1074/jbc.270.46.27804. PMID 7499250. 
  3. 3.0 3.1 "Entrez Gene: AKAP1 A kinase (PRKA) anchor protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8165. 
  4. 4.0 4.1 "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary complex with AMY-1, A-kinase anchor protein 84, and a regulatory subunit of cAMP-dependent protein kinase and is phosphorylated by its kinase". J. Biol. Chem. 277 (47): 45480–92. Nov 2002. doi:10.1074/jbc.M206201200. PMID 12223483. 
  5. "AMY-1, a c-Myc-binding protein, is localized in the mitochondria of sperm by association with S-AKAP84, an anchor protein of cAMP-dependent protein kinase". J. Biol. Chem. 276 (39): 36647–51. Sep 2001. doi:10.1074/jbc.M103885200. PMID 11483602. 
  6. 6.0 6.1 "A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system". J. Mol. Biol. 327 (3): 609–18. Mar 2003. doi:10.1016/S0022-2836(03)00093-7. PMID 12634056. 
  7. 7.0 7.1 "Analysis of A-kinase anchoring protein (AKAP) interaction with protein kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding". J. Mol. Biol. 298 (2): 329–39. April 2000. doi:10.1006/jmbi.2000.3662. PMID 10764601. 
  8. "mAKAP: an A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes". J. Cell Sci. 112 (16): 2725–36. Aug 1999. doi:10.1242/jcs.112.16.2725. PMID 10413680. 

External links

Further reading