Biology:MAP2K2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Dual specificity mitogen-activated protein kinase kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene.[1] It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.[2]
Function
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK3/ERK1.
The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.
The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.[3]
Interactions
MAP2K2 has been shown to interact with MAPK3[4][5][6] and ARAF.[7]
References
- ↑ "Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2". J Biol Chem 268 (15): 11435–9. Jun 1993. doi:10.1016/S0021-9258(18)82142-1. PMID 8388392.
- ↑ "MAP2K2 mitogen-activated protein kinase kinase 2 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene/5605.
- ↑ "Entrez Gene: MAP2K2 mitogen-activated protein kinase kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5605.
- ↑ Marti, A; Luo Z; Cunningham C; Ohta Y; Hartwig J; Stossel T P; Kyriakis J M; Avruch J (Jan 1997). "Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells". J. Biol. Chem. (UNITED STATES) 272 (5): 2620–8. doi:10.1074/jbc.272.5.2620. ISSN 0021-9258. PMID 9006895.
- ↑ Butch, E R; Guan K L (Feb 1996). "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. (UNITED STATES) 271 (8): 4230–5. doi:10.1074/jbc.271.8.4230. ISSN 0021-9258. PMID 8626767.
- ↑ Zheng, C F; Guan K L (Nov 1993). "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. (UNITED STATES) 268 (32): 23933–9. doi:10.1016/S0021-9258(20)80474-8. ISSN 0021-9258. PMID 8226933.
- ↑ Yin, Xiang L; Chen She; Yan Jun; Hu Yun; Gu Jian X (Feb 2002). "Identification of interaction between MEK2 and A-Raf-1". Biochim. Biophys. Acta (Netherlands) 1589 (1): 71–6. doi:10.1016/S0167-4889(01)00188-4. ISSN 0006-3002. PMID 11909642.
Further reading
- "Nef: "necessary and enforcing factor" in HIV infection.". Curr. HIV Res. 3 (1): 87–94. 2005. doi:10.2174/1570162052773013. PMID 15638726.
- "Modelling thymic HIV-1 Nef effects.". Curr. HIV Res. 4 (1): 57–64. 2006. doi:10.2174/157016206775197583. PMID 16454711.
- "Molecular cloning, expression, and characterization of the human mitogen-activated protein kinase p44erk1". Mol. Cell. Biol. 13 (8): 4679–90. 1993. doi:10.1128/mcb.13.8.4679. PMID 7687743.
- "Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms". Science 267 (5198): 682–5. 1995. doi:10.1126/science.7839144. PMID 7839144. Bibcode: 1995Sci...267..682D.
- "Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1". EMBO J. 13 (7): 1610–9. 1994. doi:10.1002/j.1460-2075.1994.tb06424.x. PMID 8157000.
- "Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases". J. Biol. Chem. 268 (32): 23933–9. 1993. doi:10.1016/S0021-9258(20)80474-8. PMID 8226933.
- "Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2". Mol. Cell. Biol. 13 (8): 4539–48. 1993. doi:10.1128/mcb.13.8.4539. PMID 8393135.
- "Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor". Eur. J. Biochem. 234 (1): 32–8. 1996. doi:10.1111/j.1432-1033.1995.032_c.x. PMID 8529659.
- "Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2". J. Biol. Chem. 271 (8): 4230–5. 1996. doi:10.1074/jbc.271.8.4230. PMID 8626767.
- "Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system". Oncogene 12 (10): 2213–21. 1996. PMID 8668348.
- "Chemotactic peptide-induced activation of MEK-2, the predominant isoform in human neutrophils. Inhibition by wortmannin". J. Biol. Chem. 271 (35): 21005–1011. 1996. doi:10.1074/jbc.271.35.21005. PMID 8702863.
- "Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion". Proc. Natl. Acad. Sci. U.S.A. 94 (11): 5599–604. 1997. doi:10.1073/pnas.94.11.5599. PMID 9159118. Bibcode: 1997PNAS...94.5599K.
- "Tat protein induces self-perpetuating permissivity for productive HIV-1 infection". Proc. Natl. Acad. Sci. U.S.A. 94 (15): 8116–20. 1997. doi:10.1073/pnas.94.15.8116. PMID 9223324. Bibcode: 1997PNAS...94.8116L.
- "Tat protein from HIV-1 activates MAP kinase in granular neurons and glial cells from rat cerebellum". Biochem. Biophys. Res. Commun. 238 (3): 800–5. 1997. doi:10.1006/bbrc.1997.7393. PMID 9325171.
- "Murine Ksr interacts with MEK and inhibits Ras-induced transformation". Curr. Biol. 8 (1): 46–55. 1998. doi:10.1016/S0960-9822(98)70019-3. PMID 9427625.
- "Extracellular HIV-1 Tat protein induces the rapid Ser133 phosphorylation and activation of CREB transcription factor in both Jurkat lymphoblastoid T cells and primary peripheral blood mononuclear cells". J. Immunol. 160 (8): 3891–8. 1998. doi:10.4049/jimmunol.160.8.3891. PMID 9558095.
- "Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor". Science 280 (5364): 734–7. 1998. doi:10.1126/science.280.5364.734. PMID 9563949. Bibcode: 1998Sci...280..734D.
- "Human Immunodeficiency Virus Tat Modulates the Flk-1/KDR Receptor, Mitogen-Activated Protein Kinases, and Components of Focal Adhesion in Kaposi's Sarcoma Cells". J. Virol. 72 (7): 6131–7. 1998. doi:10.1128/JVI.72.7.6131-6137.1998. PMID 9621077.
- "Activation of the 41/43 kDa mitogen-activated protein kinase signaling pathway is required for hepatocyte growth factor-induced cell scattering". Oncogene 17 (1): 57–65. 1998. doi:10.1038/sj.onc.1201905. PMID 9671314.
External links
- GeneReviews/NCBI/NIH/UW entry on Cardiofaciocutaneous Syndrome
- Overview of all the structural information available in the PDB for UniProt: P36507 (Dual specificity mitogen-activated protein kinase kinase 2) at the PDBe-KB.
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