Biology:Zinc finger protein 280b
From HandWiki
Short description: Protein found in humans
 Generic protein structure example |
Zinc finger protein 280B is a protein that in humans is encoded by the ZNF280B gene.[1]
Function
The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding.
References
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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