Biology:HOOK2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Protein Hook homolog 2 (HK2) is a protein[1] that in humans is encoded by the HOOK2 gene.[2][3]
Function
Hook proteins are cytosolic coiled-coil proteins that contain conserved N-terminal domains, which attach to microtubules, and more divergent C-terminal domains, which mediate binding to organelles. The Drosophila Hook protein is a component of the endocytic compartment.[3]
References
- ↑ "Genetic analysis of hook, a gene required for endocytic trafficking in drosophila". Genetics 151 (2): 675–84. February 1999. doi:10.1093/genetics/151.2.675. PMID 9927460.
- ↑ "The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins". J. Cell Biol. 152 (5): 923–34. March 2001. doi:10.1083/jcb.152.5.923. PMID 11238449.
- ↑ 3.0 3.1 "Entrez Gene: hook homolog 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29911.
Further reading
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex.". Mol. Biol. Cell 19 (12): 5059–71. 2008. doi:10.1091/mbc.E08-05-0473. PMID 18799622.
- "Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome.". Mol. Biol. Cell 20 (22): 4790–803. 2009. doi:10.1091/mbc.E09-07-0560. PMID 19793914.
- "Hook2 contributes to aggresome formation.". BMC Cell Biol. 8: 19. 2007. doi:10.1186/1471-2121-8-19. PMID 17540036.
- "Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function.". Traffic 8 (1): 32–46. 2007. doi:10.1111/j.1600-0854.2006.00511.x. PMID 17140400.
- "A novel hook-related protein family and the characterization of hook-related protein 1.". Traffic 6 (6): 442–58. 2005. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.
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