Biology:MKNK1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.[1][2]
Interactions
MKNK1 has been shown to interact with MAPK1[3] and Eukaryotic translation initiation factor 4 gamma.[4]
References
- ↑ "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J 16 (8): 1921–33. Jun 1997. doi:10.1093/emboj/16.8.1921. PMID 9155018.
- ↑ "Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8569.
- ↑ Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. (ENGLAND) 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMID 9155017.
- ↑ Pyronnet, S; Imataka H; Gingras A C; Fukunaga R; Hunter T; Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. (ENGLAND) 18 (1): 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMID 9878069.
Further reading
- "Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes.". J. Biol. Chem. 271 (12): 6987–97. 1996. doi:10.1074/jbc.271.12.6987. PMID 8636128.
- "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2.". EMBO J. 16 (8): 1909–20. 1997. doi:10.1093/emboj/16.8.1909. PMID 9155017.
- "Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells.". J. Biol. Chem. 273 (8): 4449–58. 1998. doi:10.1074/jbc.273.8.4449. PMID 9468497.
- "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.". EMBO J. 18 (1): 270–9. 1999. doi:10.1093/emboj/18.1.270. PMID 9878069.
- "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.". Mol. Cell. Biol. 19 (3): 1871–80. 1999. doi:10.1128/MCB.19.3.1871. PMID 10022874.
- "Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes.". Genes Dev. 14 (12): 1460–70. 2000. doi:10.1101/gad.14.12.1460. PMID 10859165.
- "Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases.". J. Biol. Chem. 275 (48): 37542–51. 2001. doi:10.1074/jbc.M003395200. PMID 10978317.
- "The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells.". Mol. Cell. Biol. 21 (3): 743–54. 2001. doi:10.1128/MCB.21.3.743-754.2001. PMID 11154262.
- "Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2.". Mol. Cell. Biol. 21 (16): 5500–11. 2001. doi:10.1128/MCB.21.16.5500-5511.2001. PMID 11463832.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport.". Exp. Cell Res. 289 (2): 211–21. 2003. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein.". J. Virol. 78 (14): 7707–16. 2004. doi:10.1128/JVI.78.14.7707-7716.2004. PMID 15220445.
- "Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk.". J. Biol. Chem. 279 (37): 38649–57. 2004. doi:10.1074/jbc.M407337200. PMID 15234964.
- "Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1.". Exp. Cell Res. 299 (2): 343–55. 2004. doi:10.1016/j.yexcr.2004.06.006. PMID 15350534.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells.". Oncogene 23 (57): 9162–72. 2005. doi:10.1038/sj.onc.1208164. PMID 15516979.
- "Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells.". J. Biol. Chem. 280 (6): 4772–8. 2005. doi:10.1074/jbc.M408356200. PMID 15563472.
- "Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells.". FEBS Lett. 578 (1–2): 31–5. 2005. doi:10.1016/j.febslet.2004.10.063. PMID 15581611.
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