Biology:PRKAG2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
5'-AMP-activated protein kinase subunit gamma-2 is an enzyme that in humans is encoded by the PRKAG2 gene.[1][2][3]
Function
AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family and encodes a protein with four CBS domains. Mutations in this gene have been associated with ventricular pre-excitation (Wolff–Parkinson–White syndrome), progressive conduction system disease and cardiac hypertrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[3]
Interactions
PRKAG2 has been shown to interact with PRKAB2[4] and PRKAB1.[4]
References
- ↑ "Mammalian AMP-activated protein kinase subfamily". J Biol Chem 271 (2): 611–4. February 1996. doi:10.1074/jbc.271.2.611. PMID 8557660.
- ↑ "Non-catalytic beta- and gamma-subunit isoforms of the 5'-AMP-activated protein kinase". J Biol Chem 271 (15): 8675–81. June 1996. doi:10.1074/jbc.271.15.8675. PMID 8621499.
- ↑ 3.0 3.1 "Entrez Gene: PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51422.
- ↑ 4.0 4.1 Cheung, P C; Salt I P; Davies S P; Hardie D G; Carling D (March 2000). "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding". Biochem. J. (ENGLAND) 346 Pt 3 (3): 659–69. doi:10.1042/0264-6021:3460659. ISSN 0264-6021. PMID 10698692.
Further reading
- "PRKAG2 cardiac syndrome: familial ventricular preexcitation, conduction system disease, and cardiac hypertrophy.". Curr. Opin. Cardiol. 17 (3): 229–34. 2002. doi:10.1097/00001573-200205000-00004. PMID 12015471.
- Gollob MH (2003). "Glycogen storage disease as a unifying mechanism of disease in the PRKAG2 cardiac syndrome.". Biochem. Soc. Trans. 31 (Pt 1): 228–31. doi:10.1042/BST0310228. PMID 12546691.
- "[AMP-activated protein kinase: how a mistake in energy gauge causes glycogen storage]". Harefuah 146 (10): 770–5, 813–4. 2007. PMID 17990392.
- "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism.". J. Immunol. 145 (11): 3699–705. 1991. doi:10.4049/jimmunol.145.11.3699. PMID 1978848.
- "Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3.". J. Clin. Invest. 96 (3): 1216–20. 1995. doi:10.1172/JCI118154. PMID 7657794. PMC 185741. http://edoc.mdc-berlin.de/1996/1/1996oa.pdf.
- "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. 1993. doi:10.1073/pnas.90.14.6676. PMID 7688126. Bibcode: 1993PNAS...90.6676H.
- "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro.". AIDS 8 (7): 1016–7. 1994. doi:10.1097/00002030-199407000-00025. PMID 7946090.
- "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix.". J. Virol. 71 (6): 4372–7. 1997. doi:10.1128/JVI.71.6.4372-4377.1997. PMID 9151826.
- "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.". FEBS Lett. 409 (3): 452–6. 1997. doi:10.1016/S0014-5793(97)00569-3. PMID 9224708.
- "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases.". J. Biol. Chem. 272 (36): 22385–8. 1997. doi:10.1074/jbc.272.36.22385. PMID 9278385.
- "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.". AIDS Res. Hum. Retroviruses 14 (10): 825–33. 1998. doi:10.1089/aid.1998.14.825. PMID 9671211.
- "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease.". Neuroimmunomodulation 5 (3–4): 184–92. 1998. doi:10.1159/000026336. PMID 9730685.
- Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- "Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.". Biochem. J. 346 Pt 3 (3): 659–69. 2000. doi:10.1042/0264-6021:3460659. PMID 10698692.
- "Molecular cloning, genomic organization, and mapping of PRKAG2, a heart abundant gamma2 subunit of 5'-AMP-activated protein kinase, to human chromosome 7q36.". Genomics 70 (2): 258–63. 2001. doi:10.1006/geno.2000.6376. PMID 11112354.
- "Mutations in the gamma(2) subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis.". Hum. Mol. Genet. 10 (11): 1215–20. 2001. doi:10.1093/hmg/10.11.1215. PMID 11371514.
- "Identification of a gene responsible for familial Wolff-Parkinson-White syndrome.". N. Engl. J. Med. 344 (24): 1823–31. 2001. doi:10.1056/NEJM200106143442403. PMID 11407343.
- "An activating mutation in the gamma1 subunit of the AMP-activated protein kinase.". FEBS Lett. 500 (3): 163–8. 2001. doi:10.1016/S0014-5793(01)02602-3. PMID 11445078.
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