Biology:S100A8

Short description: Protein-coding gene in Homo sapiens

Generic protein structure example

S100 calcium-binding protein A8 (S100A8) is a protein that in humans is encoded by the S100A8 gene. It is also known as calgranulin A.

The proteins S100A8 and S100A9 form a heterodimer called calprotectin.

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis and post COVID-19 condition.

Further reading

• "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends in Biochemical Sciences 21 (4): 134–140. April 1996. doi:10.1016/S0968-0004(96)80167-8. PMID 8701470. 
• "Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9)". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1448 (2): 200–211. December 1998. doi:10.1016/S0167-4889(98)00144-X. PMID 9920411. 
• "S100A9/S100A8: Myeloid representatives of the S100 protein family as prominent players in innate immunity". Microscopy Research and Technique 60 (6): 569–580. April 2003. doi:10.1002/jemt.10299. PMID 12645005. 
• "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules". Trends in Immunology 24 (4): 155–158. April 2003. doi:10.1016/S1471-4906(03)00062-0. PMID 12697438. 
• "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis 13 (12): 960–969. December 1992. doi:10.1002/elps.11501301199. PMID 1286667. 
• "Translocation of a small cytosolic calcium-binding protein (MRP-8) to plasma membrane correlates with human neutrophil activation". The Journal of Biological Chemistry 267 (27): 19379–19382. September 1992. doi:10.1016/S0021-9258(18)41786-3. PMID 1326551. 
• "The calcium-binding protein MRP-8 is produced by human pulmonary tumor cells". Biological Chemistry Hoppe-Seyler 372 (1): 1–4. January 1991. doi:10.1515/bchm3.1991.372.1.1. PMID 2039599. 
• "Related calcium-binding proteins map to the same subregion of chromosome 1q and to an extended region of synteny on mouse chromosome 3". Genomics 8 (3): 420–426. November 1990. doi:10.1016/0888-7543(90)90027-R. PMID 2149559. 
• "Expression pattern of two related cystic fibrosis-associated calcium-binding proteins in normal and abnormal tissues". Journal of Cell Science 91 ( Pt 2) (2): 221–230. October 1988. doi:10.1242/jcs.91.2.221. PMID 3267695. 
• "Two calcium-binding proteins in infiltrate macrophages of rheumatoid arthritis". Nature 330 (6143): 80–82. 1987. doi:10.1038/330080a0. PMID 3313057. Bibcode: 1987Natur.330...80O. 
• "Cloning and expression of two human genes encoding calcium-binding proteins that are regulated during myeloid differentiation". Molecular and Cellular Biology 8 (6): 2402–2410. June 1988. doi:10.1128/mcb.8.6.2402. PMID 3405210. 
• "A clue to the basic defect in cystic fibrosis from cloning the CF antigen gene". Nature 326 (6113): 614–617. 1987. doi:10.1038/326614a0. PMID 3561500. Bibcode: 1987Natur.326..614D. 
• "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics 25 (3): 638–643. February 1995. doi:10.1016/0888-7543(95)80005-7. PMID 7759097. 
• "Calprotectin-like protein is related to soluble organic matrix in calcium oxalate urinary stone". Biochemistry and Molecular Biology International 34 (2): 309–313. September 1994. PMID 7849642. 
• "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proceedings of the National Academy of Sciences of the United States of America 90 (14): 6547–6551. July 1993. doi:10.1073/pnas.90.14.6547. PMID 8341667. Bibcode: 1993PNAS...90.6547E. 
• "MRP8 and MRP14, S-100-like proteins associated with myeloid differentiation, are translocated to plasma membrane and intermediate filaments in a calcium-dependent manner". Blood 82 (6): 1875–1883. September 1993. doi:10.1182/blood.V82.6.1875.1875. PMID 8400238. 
• "In vitro antimicrobial activity of the human neutrophil cytosolic S-100 protein complex, calprotectin, against Capnocytophaga sputigena". Journal of Dental Research 72 (2): 517–523. February 1993. doi:10.1177/00220345930720020801. PMID 8423249. 
• "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin". Biochemical and Biophysical Research Communications 221 (2): 454–458. April 1996. doi:10.1006/bbrc.1996.0616. PMID 8619876.