Biology:Calgranulin
From HandWiki
Calgranulin is an S100 calcium-binding protein that is expressed in multiple cell types, including renal epithelial cells and neutrophils.
The proteins S100A8 and S100A9 form a heterodimer called calprotectin.
Human genes
Function
Some in vitro evidence suggests that calgranulin can inhibit the precipitation of calcium oxalate in a urine-like environment at calgranulin concentrations below physiological concentrations.[1] Thus, it may also function in vivo as an inhibitor of calcium oxalate kidney stone formation. However, the role of calgranulin in the stone formation process has not been evaluated.
See also
- Measurement of faecal calprotectin
References
- ↑ "Evidence that calgranulin is produced by kidney cells and is an inhibitor of calcium oxalate crystallization". Am J Physiol 275 (2 Pt 2): F255–61. 1 August 1998. doi:10.1152/ajprenal.1998.275.2.F255. PMID 9691016. http://ajprenal.physiology.org/cgi/content/abstract/275/2/F255.
External links
- Calgranulin+A at the US National Library of Medicine Medical Subject Headings (MeSH)
- Calgranulin+B at the US National Library of Medicine Medical Subject Headings (MeSH)
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