Biology:ACAT2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Acetyl-CoA acetyltransferase, cytosolic, also known as cytosolic acetoacetyl-CoA thiolase, is an enzyme that in humans is encoded by the ACAT2 (acetyl-Coenzyme A acetyltransferase 2) gene

Acetyl-Coenzyme A acetyltransferase 2 is an acetyl-CoA C-acetyltransferase enzyme.

Gene

This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation.

External links

• Human ACAT2 genome location and ACAT2 gene details page in the UCSC Genome Browser.

Further reading

• "Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT)". The Prostate 68 (1): 20–33. Jan 2008. doi:10.1002/pros.20674. PMID 18000807. 
• "Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk". Human Molecular Genetics 19 (10): 2068–78. May 2010. doi:10.1093/hmg/ddq079. PMID 20167577. 
• "Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks". Human Genetics 118 (3–4): 393–403. Dec 2005. doi:10.1007/s00439-005-0055-3. PMID 16195894. 
• "Prediction of genetic risk for dyslipidemia". Genomics 90 (5): 551–8. Nov 2007. doi:10.1016/j.ygeno.2007.08.001. PMID 17919884. 
• "High resolution crystal structures of human cytosolic thiolase (CT): a comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I". Journal of Molecular Biology 347 (1): 189–201. Mar 2005. doi:10.1016/j.jmb.2005.01.018. PMID 15733928. 
• "Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations". Journal of Lipid Research 49 (12): 2582–9. Dec 2008. doi:10.1194/jlr.M800232-JLR200. PMID 18660489. 
• "ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients". Atherosclerosis 207 (1): 266–71. Nov 2009. doi:10.1016/j.atherosclerosis.2009.04.010. PMID 19467657. 
• "Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells". Biochemical and Biophysical Research Communications 364 (2): 402–9. Dec 2007. doi:10.1016/j.bbrc.2007.10.028. PMID 17950700. 
• "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556. 
• "Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension". Hypertension Research 32 (5): 411–8. May 2009. doi:10.1038/hr.2009.22. PMID 19282863. 
• "Expression of two isozymes of acyl-coenzyme A: cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma". International Journal of Urology 15 (2): 166–70. Feb 2008. doi:10.1111/j.1442-2042.2007.01947.x. PMID 18269457. 
• "Two human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes". Acta Biochimica et Biophysica Sinica 37 (12): 797–806. Dec 2005. doi:10.1111/j.1745-7270.2005.00118.x. PMID 16331323. 
• "The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (−77G→A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1682 (1–3): 56–62. Jun 2004. doi:10.1016/j.bbalip.2004.01.008. PMID 15158756. 
• "Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone". Clinica Chimica Acta; International Journal of Clinical Chemistry 400 (1–2): 48–55. Feb 2009. doi:10.1016/j.cca.2008.10.009. PMID 18996102. 
• "Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients". Biochemical and Biophysical Research Communications 379 (1): 49–54. Jan 2009. doi:10.1016/j.bbrc.2008.11.131. PMID 19071091. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.