Biology:Chandelier cell
Chandelier cell | |
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Reconstruction of a mouse chandelier cell. Soma and dendrites are labeled in blue, axon arbor in red. (Woodruff & Yuste, 2008, PLoS Biology)[1] | |
Anatomical terms of neuroanatomy |
Chandelier neurons or chandelier cells are a subset of GABAergic cortical interneurons. They are described as parvalbumin-containing and fast-spiking to distinguish them from other subtypes of GABAergic neurons, although more recent work has suggested that only a subset of chandelier cells test positive for parvalbumin by immunostaining.[3] The name comes from the specific shape of their axon arbors, with the terminals forming distinct arrays called "cartridges". The cartridges are immunoreactive to an isoform of the GABA membrane transporter, GAT-1, and this serves as their identifying feature.[4][5] GAT-1 is involved in the process of GABA reuptake into nerve terminals, thus helping to terminate its synaptic activity. Chandelier neurons synapse exclusively to the axon initial segment of pyramidal neurons, near the site where action potential is generated.[6] It is believed that they provide inhibitory input to the pyramidal neurons, but there is data showing that in some circumstances the GABA from chandelier neurons could be excitatory. [7]
The axon cartridges formed by chandelier cells are one of the synapse types that show the most dramatic changes during normal adolescence,[8] and could potentially be relevant to the adult onset of psychiatric disease. Furthering this link, in schizophrenia, scientists have observed changes in their form and functionality, such as 40% decrease in the axon terminal density.[9]
See also
List of distinct cell types in the adult human body
References
- ↑ 1.0 1.1 "Of Mice and Men, and Chandeliers". PLoS Biol. 6 (9): e243. September 2008. doi:10.1371/journal.pbio.0060243. PMID 18816168.
- ↑ Yuste, Rafael, ed (September 2008). "Complex events initiated by individual spikes in the human cerebral cortex". PLoS Biol. 6 (9): e222. doi:10.1371/journal.pbio.0060222. PMID 18767905.
- ↑ "The Spatial and Temporal Origin of Chandelier Cells in Mouse Neocortex". Science 339 (6115): 70–4. January 2013. doi:10.1126/science.1227622. PMID 23180771. Bibcode: 2013Sci...339...70T.
- ↑ Borden, L. A. (1996). "GABA transporter heterogeneity: Pharmacology and cellular localization". Neurochemistry International 29 (4): 335–356. doi:10.1016/0197-0186(95)00158-1. PMID 8939442.
- ↑ Hardwick, C.; French, S. J.; Southam, E.; Totterdell, S. (2005). "A comparison of possible markers for chandelier cartridges in rat medial prefrontal cortex and hippocampus". Brain Research 1031 (2): 238–244. doi:10.1016/j.brainres.2004.10.047. PMID 15649449.
- ↑ Contreras, D. (2004). "Electrophysiological classes of neocortical neurons". Neural Networks 17 (5–6): 633–646. doi:10.1016/j.neunet.2004.04.003. PMID 15288889.
- ↑ Szabadics, J.; Varga, C.; Molnár, G.; Oláh, S.; Barzó, P.; Tamás, G. (2006). "Excitatory Effect of GABAergic Axo-Axonic Cells in Cortical Microcircuits". Science 311 (5758): 233–235. doi:10.1126/science.1121325. PMID 16410524. Bibcode: 2006Sci...311..233S.
- ↑ Anderson, S.A.; Classey, J.D.; Condé, F.; Lund, J.S.; Lewis, D.A. (1995). "Synchronous development of pyramidal neuron dendritic spines and parvalbumin-immunoreactive chandelier neuron axon terminals in layer III of monkey prefrontal cortex". Neuroscience 67 (1): 7–22. doi:10.1016/0306-4522(95)00051-J. ISSN 0306-4522. PMID 7477911.
- ↑ Pierri, J. N.; Chaudry, A. S.; Woo, T. U.; Lewis, D. A. (1999). "Alterations in chandelier neuron axon terminals in the prefrontal cortex of schizophrenic subjects". The American Journal of Psychiatry 156 (11): 1709–1719. doi:10.1176/ajp.156.11.1709. PMID 10553733.
External links
Wikimedia Commons has media related to Chandelier cell. |
- SRF interviews David Lewis - an interview touching on the GABAergic neuronal dysfunction in schizophrenia and the role of the chandelier cells.
- NIF Search - Chandelier Cell via the Neuroscience Information Framework
- Cortical Development - images of chandelier neurons and information on their developmental changes. Translational Neuroscience Program at the University of Pittsburgh.
- How chandelier cells light up human thought - A type of brain cell called a chandelier neuron might be what gives us the edge over other mammals in thought and language, New Scientist, 3 September 2008
Original source: https://en.wikipedia.org/wiki/Chandelier cell.
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