Biology:Succinylornithine transaminase
succinylornithine transaminase | |||||||||
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Succinylornithine transaminase homodimer, E.Coli | |||||||||
Identifiers | |||||||||
EC number | 2.6.1.81 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a succinylornithine transaminase (EC 2.6.1.81) is an enzyme that catalyzes the chemical reaction
- N2-succinyl-L-ornithine + 2-oxoglutarate [math]\displaystyle{ \rightleftharpoons }[/math] N-succinyl-L-glutamate 5-semialdehyde + L-glutamate
Thus, the two substrates of this enzyme are N2-succinyl-L-ornithine and 2-oxoglutarate, whereas its two products are N-succinyl-L-glutamate 5-semialdehyde and L-glutamate.
This enzyme belongs to the family of transferases, specifically the transaminases, which transfer nitrogenous groups. The systematic name of this enzyme class is N2-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase. Other names in common use include succinylornithine aminotransferase, N2-succinylornithine 5-aminotransferase, AstC, SOAT, and 2-N-succinyl-L-ornithine:2-oxoglutarate 5-aminotransferase. This enzyme participates in arginine and proline metabolism.
References
- "Occurrence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia". J. Bacteriol. 164 (2): 882–6. 1985. PMID 2865249.
- "Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli". J. Bacteriol. 180 (16): 4278–86. 1998. PMID 9696779.
- "Biosynthesis and metabolism of arginine in bacteria". Microbiol. Rev. 50 (3): 314–52. 1986. PMID 3534538.
- Itoh Y (1997). "Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa". J. Bacteriol. 179 (23): 7280–90. doi:10.1128/jb.179.23.7280-7290.1997. PMID 9393691.
- "Catabolism of arginine, citrulline and ornithine by Pseudomonas and related bacteria". J. Gen. Microbiol. 133 (9): 2487–95. 1987. doi:10.1099/00221287-133-9-2487. PMID 3129535.
Original source: https://en.wikipedia.org/wiki/Succinylornithine transaminase.
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