Biology:Condensation domain
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Revision as of 16:11, 13 June 2021 by imported>Nautica (update)
| Condensation | |||||||||
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 crystal structure of vibh, an nrps condensation enzyme | |||||||||
| Identifiers | |||||||||
| Symbol | Condensation | ||||||||
| Pfam | PF00668 | ||||||||
| Pfam clan | CL0149 | ||||||||
| InterPro | IPR001242 | ||||||||
| SCOP2 | 1l5a / SCOPe / SUPFAM | ||||||||
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In molecular biology, the condensation domain is a protein domain found in many multi-domain enzymes which synthesise peptide antibiotics. This domain catalyses a condensation reaction to form peptide bonds in non-ribosomal peptide biosynthesis. It is usually found to the carboxy side of a phosphopantetheine binding domain (pp-binding). It has been shown that mutations in the HHXXXDG sequence motif in this domain abolish activity suggesting this is part of the active site.[1]
References
- ↑ "Peptide bond formation in nonribosomal peptide biosynthesis. Catalytic role of the condensation domain". J. Biol. Chem. 273 (35): 22773–81. August 1998. doi:10.1074/jbc.273.35.22773. PMID 9712910.
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