Biology:MAPKAPK3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

MAP kinase-activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK3 gene.

Function

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation.

Interactions

MAPKAPK3 has been shown to interact with MAPK14 and TCF3.

Further reading

• "Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG". Cancer Res. 56 (7): 1487–92. 1996. PMID 8603390. 
• "A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress". FEBS Lett. 392 (3): 209–14. 1996. doi:10.1016/0014-5793(96)00816-2. PMID 8774846. 
• "3pK, a novel mitogen-activated protein (MAP) kinase-activated protein kinase, is targeted by three MAP kinase pathways". Mol. Cell. Biol. 16 (12): 6687–97. 1997. doi:10.1128/mcb.16.12.6687. PMID 8943323. 
• "Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles". Biochem. Biophys. Res. Commun. 235 (3): 533–8. 1997. doi:10.1006/bbrc.1997.6849. PMID 9207191. 
• "Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity". J. Biol. Chem. 275 (27): 20239–42. 2000. doi:10.1074/jbc.C901040199. PMID 10781029. 
• "Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions". EMBO J. 20 (3): 466–79. 2001. doi:10.1093/emboj/20.3.466. PMID 11157753. 
• "Gene activity changes in ischemically preconditioned rabbit heart gene: discovery array study". Heart Disease (Hagerstown, Md.) 4 (2): 63–9. 2002. doi:10.1097/00132580-200203000-00002. PMID 11975836. 
• "Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways". Biochem. J. 367 (Pt 2): 525–32. 2002. doi:10.1042/BJ20020916. PMID 12171600. 
• "Mitogen-activated 3p kinase is active in the nucleus". Exp. Cell Res. 299 (1): 101–9. 2004. doi:10.1016/j.yexcr.2004.05.027. PMID 15302577. 
• "MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1". J. Biol. Chem. 280 (7): 5178–87. 2005. doi:10.1074/jbc.M407155200. PMID 15563468. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.