Biology:RNF125
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
E3 ubiquitin-protein ligase RNF125 is an enzyme that in humans is encoded by the RNF125 gene.[1]
This gene encodes a novel E3 ubiquitin ligase that contains an N-terminal RING finger domain. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway.[1]
References
Further reading
- "T-cell regulator RNF125/TRAC-1 belongs to a novel family of ubiquitin ligases with zinc fingers and a ubiquitin-binding domain.". Biochem. J. 410 (1): 101–11. 2008. doi:10.1042/BJ20070995. PMID 17990982.
- "The RING finger ubiquitin ligase RNF125/TRAC-1 down-modulates HIV-1 replication in primary human peripheral blood mononuclear cells.". Virology 368 (1): 191–204. 2007. doi:10.1016/j.virol.2007.06.028. PMID 17643463.
- "A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation.". J. Immunol. 174 (9): 5288–97. 2005. doi:10.4049/jimmunol.174.9.5288. PMID 15843525.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Systematic identification of regulatory proteins critical for T-cell activation.". J. Biol. 2 (3): 21. 2004. doi:10.1186/1475-4924-2-21. PMID 12974981.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Does this have a familiar RING?". Trends Biochem. Sci. 21 (6): 208–14. 1996. doi:10.1016/s0968-0004(96)80017-x. PMID 8744354.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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