Biology:ACP2

Short description: Protein-coding gene in humans

Generic protein structure example

Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.

Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.

Further reading

• "Clinical and biological aspects of acid phosphatase.". Critical Reviews in Clinical Laboratory Sciences 32 (4): 431–67. 1995. doi:10.3109/10408369509084690. PMID 7576159. 
• "Intracellular enzymatic response of lymphocytes and neutrophils in patients with cancer of the larynx.". Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 104 (2): 208–15. 1977. PMID 69583. 
• "Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11.". Hum. Genet. 45 (1): 1–10. 1979. doi:10.1007/BF00277567. PMID 730175. 
• "Structure of the human lysosomal acid phosphatase gene.". Eur. J. Biochem. 183 (3): 611–6. 1989. doi:10.1111/j.1432-1033.1989.tb21090.x. PMID 2776754. 
• "Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts.". J. Biol. Chem. 260 (15): 9023–30. 1985. doi:10.1016/S0021-9258(17)39452-8. PMID 3160696. 
• "Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment.". EMBO J. 7 (8): 2343–50. 1989. doi:10.1002/j.1460-2075.1988.tb03078.x. PMID 3191910. 
• "Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells.". Arch. Biochem. Biophys. 243 (1): 274–83. 1985. doi:10.1016/0003-9861(85)90796-9. PMID 3904632. 
• "Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder.". N. Engl. J. Med. 282 (6): 302–7. 1970. doi:10.1056/NEJM197002052820604. PMID 5410815. 
• "Activation of lysosomal acid phosphatase of eosinophil leukocytes.". Lab. Invest. 44 (5): 403–9. 1981. PMID 6164873. 
• "Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies.". Basic and Applied Histochemistry 27 (2): 75–85. 1983. PMID 6193776. 
• "Beta-glucuronidase of lymphocytes in ontogenetic development of man.". Arch. Immunol. Ther. Exp. (Warsz.) 31 (2): 171–6. 1984. PMID 6651479. 
• "Isoelectric focusing pattern of acid phosphatase and acid esterase in human blood cells, including thymocytes, T lymphocytes, and B lymphocytes.". Exp. Hematol. 8 (6): 737–41. 1981. PMID 6970673. 
• "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 
• "Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas.". Invest. Ophthalmol. Vis. Sci. 38 (2): 529–34. 1997. PMID 9040486. 
• "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174. 
• "The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targeting to lysosomes.". J. Cell Sci. 115 (Pt 1): 185–94. 2002. doi:10.1242/jcs.115.1.185. PMID 11801736. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 

External links

• Human ACP2 genome location and ACP2 gene details page in the UCSC Genome Browser.