Biology:ACP2
From HandWiki
Short description: Protein-coding gene in humans
![]() Generic protein structure example |
Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.[1][2]
Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.[2]
References
- ↑ "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11". Cytogenet Cell Genet 16 (1–5): 231–4. Dec 1976. doi:10.1159/000130598. PMID 975882.
- ↑ 2.0 2.1 "Entrez Gene: ACP2 acid phosphatase 2, lysosomal". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53.
Further reading
- "Clinical and biological aspects of acid phosphatase.". Critical Reviews in Clinical Laboratory Sciences 32 (4): 431–67. 1995. doi:10.3109/10408369509084690. PMID 7576159.
- "Intracellular enzymatic response of lymphocytes and neutrophils in patients with cancer of the larynx.". Folia Haematol. Int. Mag. Klin. Morphol. Blutforsch. 104 (2): 208–15. 1977. PMID 69583.
- "Regional mapping of the gene for human lysosomal acid phosphatase (ACP2) using a hybrid clone panel containing segments of human chromosome 11.". Hum. Genet. 45 (1): 1–10. 1979. doi:10.1007/BF00277567. PMID 730175.
- "Structure of the human lysosomal acid phosphatase gene.". Eur. J. Biochem. 183 (3): 611–6. 1989. doi:10.1111/j.1432-1033.1989.tb21090.x. PMID 2776754.
- "Synthesis and transport of lysosomal acid phosphatase in normal and I-cell fibroblasts.". J. Biol. Chem. 260 (15): 9023–30. 1985. doi:10.1016/S0021-9258(17)39452-8. PMID 3160696.
- "Human lysosomal acid phosphatase: cloning, expression and chromosomal assignment.". EMBO J. 7 (8): 2343–50. 1989. doi:10.1002/j.1460-2075.1988.tb03078.x. PMID 3191910.
- "Biosynthesis and processing of lysosomal acid phosphatase in cultured human cells.". Arch. Biochem. Biophys. 243 (1): 274–83. 1985. doi:10.1016/0003-9861(85)90796-9. PMID 3904632.
- "Deficiency of lysosomal acid phosphatase. A new familial metabolic disorder.". N. Engl. J. Med. 282 (6): 302–7. 1970. doi:10.1056/NEJM197002052820604. PMID 5410815.
- "Activation of lysosomal acid phosphatase of eosinophil leukocytes.". Lab. Invest. 44 (5): 403–9. 1981. PMID 6164873.
- "Histochemical identification of osteoclasts. Review of current methods and reappraisal of a simple procedure for routine diagnosis on undecalcified human iliac bone biopsies.". Basic and Applied Histochemistry 27 (2): 75–85. 1983. PMID 6193776.
- "Beta-glucuronidase of lymphocytes in ontogenetic development of man.". Arch. Immunol. Ther. Exp. (Warsz.) 31 (2): 171–6. 1984. PMID 6651479.
- "Isoelectric focusing pattern of acid phosphatase and acid esterase in human blood cells, including thymocytes, T lymphocytes, and B lymphocytes.". Exp. Hematol. 8 (6): 737–41. 1981. PMID 6970673.
- "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Cathepsin G, acid phosphatase, and alpha 1-proteinase inhibitor messenger RNA levels in keratoconus corneas.". Invest. Ophthalmol. Vis. Sci. 38 (2): 529–34. 1997. PMID 9040486.
- "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174.
- "The tyrosine motifs of Lamp 1 and LAP determine their direct and indirect targeting to lysosomes.". J. Cell Sci. 115 (Pt 1): 185–94. 2002. doi:10.1242/jcs.115.1.185. PMID 11801736.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
External links
- Human ACP2 genome location and ACP2 gene details page in the UCSC Genome Browser.
![]() | Original source: https://en.wikipedia.org/wiki/ACP2.
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