Biology:FBP1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Fructose-1,6-bisphosphatase 1 is a protein that in humans is encoded by the FBP1 gene.[1]
Function
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: Fructose-1,6-bisphosphatase 1". https://www.ncbi.nlm.nih.gov/gene/2203. Retrieved 2014-04-19.
Further reading
- "Novel expression of liver FBPase in Langerhans islets of human and rat pancreas". Journal of Cellular Physiology 205 (1): 19–24. Oct 2005. doi:10.1002/jcp.20407. PMID 15965961.
- "Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency". European Journal of Pediatrics 168 (12): 1467–71. Dec 2009. doi:10.1007/s00431-009-0953-9. PMID 19259699.
- "cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency". Biochemical and Biophysical Research Communications 199 (2): 687–93. Mar 1994. doi:10.1006/bbrc.1994.1283. PMID 8135811.
- "HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase". Journal of Interferon & Cytokine Research 17 (8): 461–7. Aug 1997. doi:10.1089/jir.1997.17.461. PMID 9282826.
- "Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence". Proteins 77 (2): 262–7. Nov 2009. doi:10.1002/prot.22506. PMID 19626708.
- "Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase". Biochemistry 32 (7): 1844–57. Feb 1993. doi:10.1021/bi00058a019. PMID 8382525.
- "The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity". Diabetes 61 (5): 1122–32. May 2012. doi:10.2337/db11-1511. PMID 22517657.
- "Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis". Oncogene 29 (3): 442–50. Jan 2010. doi:10.1038/onc.2009.332. PMID 19881551.
- "Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency". American Journal of Human Genetics 61 (4): 852–61. Oct 1997. doi:10.1086/514875. PMID 9382095.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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