Biology:FBP1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Fructose-1,6-bisphosphatase 1 is a protein that in humans is encoded by the FBP1 gene.[1]
Function
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis.[1]The human FBP1 gene was cloned in 1988 by Solomon and colleagues at Memorial Sloan Kettering Cancer Center, who reported the cDNA sequence and expression pattern of the enzyme fructose‑1,6‑bisphosphatase in human tissues.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: Fructose-1,6-bisphosphatase 1". https://www.ncbi.nlm.nih.gov/gene/2203. Retrieved 2014-04-19.
- ↑ Solomon DH, Raynal MC, Tejwani GA, Cayre YE. Cloning and characterization of human fructose‑1,6‑bisphosphatase. Proc Natl Acad Sci U S A. 1988;85(18):6904–6908. doi:10.1073/pnas.85.18.6904.
Further reading
- "Novel expression of liver FBPase in Langerhans islets of human and rat pancreas". Journal of Cellular Physiology 205 (1): 19–24. Oct 2005. doi:10.1002/jcp.20407. PMID 15965961.
- "Novel FBP1 gene mutations in Arab patients with fructose-1,6-bisphosphatase deficiency". European Journal of Pediatrics 168 (12): 1467–71. Dec 2009. doi:10.1007/s00431-009-0953-9. PMID 19259699.
- "cDNA sequences encoding human fructose 1,6-bisphosphatase from monocytes, liver and kidney: application of monocytes to molecular analysis of human fructose 1,6-bisphosphatase deficiency". Biochemical and Biophysical Research Communications 199 (2): 687–93. Mar 1994. doi:10.1006/bbrc.1994.1283. PMID 8135811.
- "HIV-1 p17 and IFN-gamma both induce fructose 1,6-bisphosphatase". Journal of Interferon & Cytokine Research 17 (8): 461–7. Aug 1997. doi:10.1089/jir.1997.17.461. PMID 9282826.
- "Muscle FBPase is targeted to nucleus by its 203KKKGK207 sequence". Proteins 77 (2): 262–7. Nov 2009. doi:10.1002/prot.22506. PMID 19626708.
- "Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase". Biochemistry 32 (7): 1844–57. Feb 1993. doi:10.1021/bi00058a019. PMID 8382525.
- "The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity". Diabetes 61 (5): 1122–32. May 2012. doi:10.2337/db11-1511. PMID 22517657.
- "Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis". Oncogene 29 (3): 442–50. Jan 2010. doi:10.1038/onc.2009.332. PMID 19881551.
- "Identification of genetic mutations in Japanese patients with fructose-1,6-bisphosphatase deficiency". American Journal of Human Genetics 61 (4): 852–61. Oct 1997. doi:10.1086/514875. PMID 9382095.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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