Biology:PEST sequence
From HandWiki
Short description: Peptide sequence in short-lived proteins
A PEST sequence is a peptide sequence that is rich in proline (P), glutamic acid (E), serine (S) and threonine (T). It is associated with proteins that have a short intracellular half-life, so might act as a signal peptide for protein degradation.[1] This may be mediated via the proteasome[2][3] or calpain.[4]
References
- ↑ "Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis". Science 234 (4774): 364–8. 1986. doi:10.1126/science.2876518. PMID 2876518. Bibcode: 1986Sci...234..364R.
- ↑ "CPEB degradation during Xenopus oocyte maturation requires a PEST domain and the 26S proteasome". Dev. Biol. 231 (2): 447–58. 2001. doi:10.1006/dbio.2001.0153. PMID 11237472.
- ↑ "NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif". J. Biol. Chem. 279 (35): 37069–78. 2004. doi:10.1074/jbc.M402507200. PMID 15229225.
- ↑ "The PEST Domain of IκBα is necessary and sufficient for in vitro degradation by mu-calpain". J. Biol. Chem. 274 (43): 30874–81. 1999. doi:10.1074/jbc.274.43.30874. PMID 10521480.
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