Biology:RPS6KA1
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Short description: Enzyme
 Generic protein structure example |
Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.[1]
Function
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
Interactions
RPS6KA1 has been shown to interact with:
See also
References
- ↑ "Human rsk isoforms: cloning and characterization of tissue-specific expression". The American Journal of Physiology 266 (2 Pt 1): C351–9. Feb 1994. doi:10.1152/ajpcell.1994.266.2.C351. PMID 8141249.
- ↑ "Entrez Gene: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6195.
- ↑ "IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase". The EMBO Journal 16 (11): 3133–44. Jun 1997. doi:10.1093/emboj/16.11.3133. PMID 9214631.
- ↑ "Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity". Molecular and Cellular Biology 23 (14): 4796–804. Jul 2003. doi:10.1128/mcb.23.14.4796-4804.2003. PMID 12832467.
- ↑ "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". The Journal of Biological Chemistry 278 (17): 14926–35. Apr 2003. doi:10.1074/jbc.M300485200. PMID 12594221.
- ↑ "Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo". The Journal of Biological Chemistry 274 (5): 2893–8. Jan 1999. doi:10.1074/jbc.274.5.2893. PMID 9915826.
- ↑ "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes to Cells 6 (2): 131–8. Feb 2001. doi:10.1046/j.1365-2443.2001.00406.x. PMID 11260258.
- ↑ "Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase". Proceedings of the National Academy of Sciences of the United States of America 101 (37): 13489–94. Sep 2004. doi:10.1073/pnas.0405659101. PMID 15342917. Bibcode: 2004PNAS..10113489R.
- ↑ "Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2)". The Biochemical Journal 388 (Pt 3): 973–84. Jun 2005. doi:10.1042/BJ20041888. PMID 15757502.
- ↑ "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity". The Journal of Biological Chemistry 278 (20): 18376–83. May 2003. doi:10.1074/jbc.M208475200. PMID 12618428.
Further reading
- "Nuclear localization and regulation of erk- and rsk-encoded protein kinases". Molecular and Cellular Biology 12 (3): 915–27. Mar 1992. doi:10.1128/mcb.12.3.915. PMID 1545823.
- "Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential". Molecular and Cellular Biology 12 (3): 998–1006. Mar 1992. doi:10.1128/mcb.12.3.998. PMID 1545828.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase". Proceedings of the National Academy of Sciences of the United States of America 90 (23): 10952–6. Dec 1993. doi:10.1073/pnas.90.23.10952. PMID 8248197. Bibcode: 1993PNAS...9010952C.
- "A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity". Molecular and Cellular Biology 13 (10): 6260–73. Oct 1993. doi:10.1128/mcb.13.10.6260. PMID 8413226.
- "Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity". Cell 84 (6): 853–62. Mar 1996. doi:10.1016/S0092-8674(00)81064-8. PMID 8601309.
- "Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route". Blood 87 (6): 2148–53. Mar 1996. doi:10.1182/blood.V87.6.2148.bloodjournal8762148. PMID 8630373.
- "Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1". The Journal of Biological Chemistry 271 (30): 18217–23. Jul 1996. doi:10.1074/jbc.271.30.18217. PMID 8663493.
- "Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase". Science 273 (5277): 959–63. Aug 1996. doi:10.1126/science.273.5277.959. PMID 8688081. Bibcode: 1996Sci...273..959X.
- "The signal-dependent coactivator CBP is a nuclear target for pp90RSK". Cell 86 (3): 465–74. Aug 1996. doi:10.1016/S0092-8674(00)80119-1. PMID 8756728.
- "Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases". The Journal of Biological Chemistry 271 (47): 29773–9. Nov 1996. doi:10.1074/jbc.271.47.29773. PMID 8939914.
- "Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA". The Journal of Biological Chemistry 272 (8): 5183–6. Feb 1997. doi:10.1074/jbc.272.8.5183. PMID 9030586.
- "IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase". The EMBO Journal 16 (11): 3133–44. Jun 1997. doi:10.1093/emboj/16.11.3133. PMID 9214631.
- "Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells". The Journal of Biological Chemistry 272 (29): 18200–8. Jul 1997. doi:10.1074/jbc.272.29.18200. PMID 9218456.
- "Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation". The Journal of Biological Chemistry 272 (45): 28252–7. Nov 1997. doi:10.1074/jbc.272.45.28252. PMID 9353277.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt". Science 278 (5338): 687–9. Oct 1997. doi:10.1126/science.278.5338.687. PMID 9381178. Bibcode: 1997Sci...278..687D.
- "Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK". The Journal of Biological Chemistry 273 (3): 1496–505. Jan 1998. doi:10.1074/jbc.273.3.1496. PMID 9430688.
- "pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167". Molecular and Cellular Biology 18 (4): 1978–84. Apr 1998. doi:10.1128/mcb.18.4.1978. PMID 9528769.
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