Biology:GAPDHS
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic or glyceraldehyde-3-phosphate dehydrogenase, testis-specific is an enzyme that in humans is encoded by the GAPDHS gene.[1][2]
Function
This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.[2]
In melanocytic cells GAPDHS gene expression may be regulated by MITF.[3]
Interactive pathway map
References
- ↑ "Human glyceraldehyde 3-phosphate dehydrogenase-2 gene is expressed specifically in spermatogenic cells". Journal of Andrology 21 (2): 328–38. Apr 2000. doi:10.1002/j.1939-4640.2000.tb02111.x. PMID 10714828.
- ↑ 2.0 2.1 "Entrez Gene: GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26330.
- ↑ "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research 21 (6): 665–76. Dec 2008. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
Further reading
- "Approaches to post-testicular contraception". Asian Journal of Andrology 1 (1–2): 29–36. Jun 1999. PMID 11225901.
- "Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations". Genomics 5 (2): 209–14. Aug 1989. doi:10.1016/0888-7543(89)90048-7. PMID 2793178.
- "Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa" (PDF). Biology of Reproduction 8 (3): 350–7. Apr 1973. PMID 4349855. http://www.biolreprod.org/content/8/3/350.full.pdf+html. Retrieved 2011-10-14.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa". Journal of Cell Science 110 (15): 1821–9. Aug 1997. doi:10.1242/jcs.110.15.1821. PMID 9264469.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa". Molecular Human Reproduction 6 (2): 127–36. Feb 2000. doi:10.1093/molehr/6.2.127. PMID 10655454.
- "Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro". Journal of Andrology 22 (3): 464–70. 2001. PMID 11330647.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family". Proceedings of the National Academy of Sciences of the United States of America 101 (44): 15688–93. Nov 2004. doi:10.1073/pnas.0403535101. PMID 15507493. Bibcode: 2004PNAS..10115688L.
- "Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+)". Genes to Cells 10 (12): 1211–9. Dec 2005. doi:10.1111/j.1365-2443.2005.00911.x. PMID 16324157.
- "Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis". Molecular Reproduction and Development 73 (8): 1052–60. Aug 2006. doi:10.1002/mrd.20235. PMID 16700075. https://zenodo.org/record/1229296.
- "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Human Molecular Genetics 15 (23): 3411–9. Dec 2006. doi:10.1093/hmg/ddl417. PMID 17047026.
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
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