Biology:GAPDHS

Short description: Enzyme of the glycolysis metabolic pathway

Generic protein structure example

Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic or glyceraldehyde-3-phosphate dehydrogenase, testis-specific is an enzyme that in humans is encoded by the GAPDHS gene.

Function

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility.

In melanocytic cells GAPDHS gene expression may be regulated by MITF.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

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Glycolysis and Gluconeogenesis edit

Further reading

• "Approaches to post-testicular contraception". Asian Journal of Andrology 1 (1–2): 29–36. Jun 1999. PMID 11225901. 
• "Members of the human glyceraldehyde-3-phosphate dehydrogenase-related gene family map to dispersed chromosomal locations". Genomics 5 (2): 209–14. Aug 1989. doi:10.1016/0888-7543(89)90048-7. PMID 2793178. 
• "Effects of (H + ), (Na + ), (K + ) and certain membrane-active drugs on glycolysis, motility, and ATP synthesis by human spermatozoa" (PDF). Biology of Reproduction 8 (3): 350–7. Apr 1973. PMID 4349855. http://www.biolreprod.org/content/8/3/350.full.pdf+html. Retrieved 2011-10-14. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Glyceraldehyde 3-phosphate dehydrogenase is bound to the fibrous sheath of mammalian spermatozoa". Journal of Cell Science 110 (15): 1821–9. Aug 1997. doi:10.1242/jcs.110.15.1821. PMID 9264469. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "L-type voltage-dependent calcium channel alpha-1C subunit mRNA is present in ejaculated human spermatozoa". Molecular Human Reproduction 6 (2): 127–36. Feb 2000. doi:10.1093/molehr/6.2.127. PMID 10655454. 
• "Susceptibility of glycolytic enzyme activity and motility of spermatozoa from rat, mouse, and human to inhibition by proven and putative chlorinated antifertility compounds in vitro". Journal of Andrology 22 (3): 464–70. 2001. doi:10.1002/j.1939-4640.2001.tb02203.x. PMID 11330647. 
• "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556. 
• "Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family". Proceedings of the National Academy of Sciences of the United States of America 101 (44): 15688–93. Nov 2004. doi:10.1073/pnas.0403535101. PMID 15507493. Bibcode: 2004PNAS..10115688L. 
• "Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+)". Genes to Cells 10 (12): 1211–9. Dec 2005. doi:10.1111/j.1365-2443.2005.00911.x. PMID 16324157. 
• "Expression of the spermatogenic cell-specific glyceraldehyde 3-phosphate dehydrogenase (GAPDS) in rat testis". Molecular Reproduction and Development 73 (8): 1052–60. Aug 2006. doi:10.1002/mrd.20235. PMID 16700075. https://zenodo.org/record/1229296. 
• "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Human Molecular Genetics 15 (23): 3411–9. Dec 2006. doi:10.1093/hmg/ddl417. PMID 17047026. 
• "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1). 2007. doi:10.1038/msb4100134. PMID 17353931.