Biology:ACAD10
 Generic protein structure example |
Acyl-CoA dehydrogenase family, member 10 is a protein that in humans is encoded by the ACAD10 gene.[1]
Structure
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catalytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[1]
Clinical significance
In Pima people, ACAD10 has been identified as a gene associated with type 2 diabetes, insulin resistance, and impaired lipid metabolism. Specifically, two single nucleotide polymorphisms, rs601663 and rs659964, have been significantly correlated with these symptoms in a large population of both the Pima people and American Indians.[2]
Interactions
Using affinity capture mass spectrometry, an interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. Using this method, ACAD10 has been shown to interact with P2RY8, NDUFA10, NTRK3, SLC2A12, LPAR4, PTH1R, COLEC10, APP, MAS1, CD79A, BSG, and Ubiquitin C.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: Acyl-CoA dehydrogenase family, member 10". https://www.ncbi.nlm.nih.gov/gene/80724.
- ↑ "Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians". Diabetologia 53 (7): 1349–53. Jul 2010. doi:10.1007/s00125-010-1695-y. PMID 20390405.
- ↑ "ACAD10 Results Summary". TheTyerslab.com. http://thebiogrid.org/123274. Retrieved 18 May 2015.
External links
- Human ACAD10 genome location and ACAD10 gene details page in the UCSC Genome Browser.
Further reading
- "Cloning and characterization of a human cDNA ACAD10 mapped to chromosome 12q24.1". Molecular Biology Reports 31 (3): 191–5. Sep 2004. doi:10.1023/b:mole.0000043622.57408.6b. PMID 15560374.
- "Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study". Gynecologic Oncology 112 (1): 210–4. Jan 2009. doi:10.1016/j.ygyno.2008.09.012. PMID 18950845.
- "Identification and characterization of new long chain acyl-CoA dehydrogenases". Molecular Genetics and Metabolism 102 (4): 418–29. Apr 2011. doi:10.1016/j.ymgme.2010.12.005. PMID 21237683.
- "A meta-analysis and genome-wide association study of platelet count and mean platelet volume in African Americans". PLOS Genetics 8 (3): e1002491. 2012. doi:10.1371/journal.pgen.1002491. PMID 22423221.
- "A genome-wide association study of a coronary artery disease risk variant". Journal of Human Genetics 58 (3): 120–6. Mar 2013. doi:10.1038/jhg.2012.124. PMID 23364394.
- "Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians". Diabetologia 53 (7): 1349–53. Jul 2010. doi:10.1007/s00125-010-1695-y. PMID 20390405.
- "Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations". Nature Genetics 43 (7): 679–84. Jul 2011. doi:10.1038/ng.849. PMID 21642993.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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