Biology:P2RY8
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.[1][2]
Function
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y.[2]
Clinical relevance
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[3]
See also
References
- ↑ "Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1492 (1): 127–38. Jun 2000. doi:10.1016/S0167-4781(00)00094-4. PMID 11004484.
- ↑ 2.0 2.1 "Entrez Gene: P2RY8 purinergic receptor P2Y, G-protein coupled, 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=286530.
- ↑ "Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing". Proceedings of the National Academy of Sciences of the United States of America 109 (10): 3879–84. Mar 2012. doi:10.1073/pnas.1121343109. PMID 22343534. Bibcode: 2012PNAS..109.3879L.
Further reading
- "Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males". Journal of Medical Genetics 41 (10): 736–42. Oct 2004. doi:10.1136/jmg.2004.021626. PMID 15466006.
- "Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening". Leukemia & Lymphoma 48 (5): 978–86. May 2007. doi:10.1080/10428190701225882. PMID 17487742.
- "Upregulation of the SOX5 by promoter swapping with the P2RY8 gene in primary splenic follicular lymphoma". Leukemia 21 (10): 2221–5. Oct 2007. doi:10.1038/sj.leu.2404784. PMID 17554380.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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