Biology:MAS1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA, MAS, MGRA""), is a protein that in humans is encoded by the MAS1 gene. The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices. The MAS1 protein may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects.

Agonists of the receptor include angiotensin-(1-7). Antagonist include A-779 (angiotensin-1-7 with c-terminal proline substituted for D-Ala), or D-Pro (angiotensin-1-7 with c-terminal proline submitted for D-proline).

Mas1 proto-oncogene (MAS1, MGRA) is not to be confused with the MAS-related G-protein coupled receptor, a recently believed to be activated by the ligand alamandine (generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7)).

See also

• MAS1 oncogene

Further reading

• "Molecular and cell biology of angiotensin receptors". Journal of Cardiovascular Pharmacology 18 (Suppl 2): S7-13. 1992. doi:10.1097/00005344-199106182-00003. PMID 1725048. 
• "The mas Oncogene as a Neural Peptide Receptor: Expression, Regulation and Mechanism of Action". Ciba Foundation Symposium 150 ‐ Proto‐Oncogenes in Cell Development. Novartis Foundation Symposia. 150. 1990. 23–38; discussion 38–46. doi:10.1002/9780470513927.ch3. ISBN 9780470513927. 
• "Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements". Oncogene Research 1 (2): 169–78. Jul 1987. PMID 3329713. 
• "The mas oncogene encodes an angiotensin receptor". Nature 335 (6189): 437–40. Sep 1988. doi:10.1038/335437a0. PMID 3419518. Bibcode: 1988Natur.335..437J. 
• "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". Cell 45 (5): 711–9. Jun 1986. doi:10.1016/0092-8674(86)90785-3. PMID 3708691. 
• "The MAS proto-oncogene is not imprinted in humans". Genomics 35 (2): 380–2. Jul 1996. doi:10.1006/geno.1996.0372. PMID 8661154. 
• "Degeneration of cone photoreceptors induced by expression of the Mas1 protooncogene". Experimental Neurology 163 (1): 207–19. May 2000. doi:10.1006/exnr.2000.7370. PMID 10785460. 
• "Cell type-specific expression of the Mas proto-oncogene in testis". The Journal of Histochemistry and Cytochemistry 50 (5): 691–6. May 2002. doi:10.1177/002215540205000510. PMID 11967280. 
• "Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas". Proceedings of the National Academy of Sciences of the United States of America 100 (14): 8258–63. Jul 2003. doi:10.1073/pnas.1432869100. PMID 12829792. Bibcode: 2003PNAS..100.8258S. 
• "Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS". The Journal of Biological Chemistry 281 (24): 16757–67. Jun 2006. doi:10.1074/jbc.M601121200. PMID 16611642. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.