Biology:ATG4A
 Generic protein structure example |
Cysteine protease ATG4A is an enzyme that in humans is encoded by the ATG4A gene.[1][2]
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodelling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Transcript variants that encode distinct isoforms have been identified.[2]
References
- ↑ "The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A". J Biol Chem 278 (16): 14053–8. Apr 2003. doi:10.1074/jbc.M212108200. PMID 12473658.
- ↑ 2.0 2.1 "Entrez Gene: ATG4A ATG4 autophagy related 4 homolog A (S. cerevisiae)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=115201.
External links
- Human ATG4A genome location and ATG4A gene details page in the UCSC Genome Browser.
Further reading
- "Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4". EMBO J. 26 (7): 1749–60. 2007. doi:10.1038/sj.emboj.7601623. PMID 17347651.
- "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation". J. Cell Sci. 117 (Pt 13): 2805–12. 2005. doi:10.1242/jcs.01131. PMID 15169837.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
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