Biology:NWD1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species.[1] The NWD1 gene of humans is located on chromosome 19. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.[2]
References
- ↑ "Conservation and divergence of gene families encoding components of innate immune response systems in zebrafish". Genome Biol. 8 (11): R251. 2007. doi:10.1186/gb-2007-8-11-r251. PMID 18039395.
- ↑ "The NLR-related protein NWD1 is associated with prostate cancer and modulates androgen receptor signaling". Oncotarget 5 (6): 1657–1665. 2014. doi:10.18632/oncotarget.1850. PMID 24681825.
Further reading
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1996. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "NLRs: Sentinels of innate immunity or cancer culprits?". Oncoscience 1 (5): 308–9. 2014. doi:10.18632/oncoscience.44. PMID 25594025.
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