Biology:BAG1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.[1]
Function
The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.[2]
Clinical significance
BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.[3]
Interactions
BAG1 has been shown to interact with:
- Androgen receptor,[4][5][6]
- C-Raf,[7]
- Calcitriol receptor,[8]
- Glucocorticoid receptor,[9][10]
- HSPA8,[11][12]
- HBEGF,[13]
- PPP1R15A,[14]
- NR1B1,[15] and
- SIAH1.[16]
References
- ↑ "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell 80 (2): 279–84. March 1995. doi:10.1016/0092-8674(95)90410-7. PMID 7834747.
- ↑ "Entrez Gene: BAG1 BCL2-associated athanogene". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=573.
- ↑ "Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3". EMBO J. 28 (7): 889–901. 2009. doi:10.1038/emboj.2009.29. PMID 19229298. *Lay summary in: "Old Cells Work Differently". March 1, 2009. https://phys.org/news/2009-03-cells-differently.html.
- ↑ "The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor". Mol. Cell. Biol. 23 (20): 7189–97. October 2003. doi:10.1128/mcb.23.20.7189-7197.2003. PMID 14517289.
- ↑ "Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity". J. Biol. Chem. 276 (16): 12718–24. April 2001. doi:10.1074/jbc.M010841200. PMID 11278763.
- ↑ "BAG-1L protein enhances androgen receptor function". J. Biol. Chem. 273 (19): 11660–6. May 1998. doi:10.1074/jbc.273.19.11660. PMID 9565586.
- ↑ "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7063–8. July 1996. doi:10.1073/pnas.93.14.7063. PMID 8692945. Bibcode: 1996PNAS...93.7063W.
- ↑ "BAG1L enhances trans-activation function of the vitamin D receptor". J. Biol. Chem. 275 (52): 40749–56. Dec 2000. doi:10.1074/jbc.M004977200. PMID 10967105.
- ↑ "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis". J. Biol. Chem. 273 (23): 14620–5. June 1998. doi:10.1074/jbc.273.23.14620. PMID 9603979.
- ↑ "Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor". EMBO J. 19 (23): 6508–16. Dec 2000. doi:10.1093/emboj/19.23.6508. PMID 11101523.
- ↑ "BAG-1 modulates the chaperone activity of Hsp70/Hsc70". EMBO J. 16 (16): 4887–96. August 1997. doi:10.1093/emboj/16.16.4887. PMID 9305631.
- ↑ "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J. Biol. Chem. 274 (2): 781–6. January 1999. doi:10.1074/jbc.274.2.781. PMID 9873016.
- ↑ "BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation". J. Biol. Chem. 276 (32): 30127–32. August 2001. doi:10.1074/jbc.M010237200. PMID 11340068.
- ↑ "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions". Mol. Cell. Biol. 23 (10): 3477–86. May 2003. doi:10.1128/mcb.23.10.3477-3486.2003. PMID 12724406.
- ↑ "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells". J. Biol. Chem. 273 (27): 16985–92. July 1998. doi:10.1074/jbc.273.27.16985. PMID 9642262.
- ↑ "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1". EMBO J. 17 (10): 2736–47. May 1998. doi:10.1093/emboj/17.10.2736. PMID 9582267.
External links
- Human BAG1 genome location and BAG1 gene details page in the UCSC Genome Browser.
Further reading
- Tang SC (2003). "BAG-1, an anti-apoptotic tumour marker.". IUBMB Life 53 (2): 99–105. doi:10.1080/15216540211473. PMID 12049201.
- "The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.". Biochem. Soc. Trans. 33 (Pt 4): 676–8. 2005. doi:10.1042/BST0330676. PMID 16042572.
- Gehring U (2007). "Activities of the cochaperones Hap46/BAG-1M and Hap50/BAG-1L and isoforms.". Cell Stress & Chaperones 11 (4): 295–303. doi:10.1379/1466-1268(2006)11[295:aotcba2.0.co;2]. PMID 17278878.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 92 (25): 11465–9. 1996. doi:10.1073/pnas.92.25.11465. PMID 8524784.
- "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7063–8. 1996. doi:10.1073/pnas.93.14.7063. PMID 8692945. Bibcode: 1996PNAS...93.7063W.
- "Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12.". Genomics 35 (3): 494–8. 1996. doi:10.1006/geno.1996.0389. PMID 8812483.
- "HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.". EMBO J. 15 (22): 6205–12. 1997. doi:10.1002/j.1460-2075.1996.tb01009.x. PMID 8947043.
- "BAG-1 modulates the chaperone activity of Hsp70/Hsc70.". EMBO J. 16 (16): 4887–96. 1997. doi:10.1093/emboj/16.16.4887. PMID 9305631.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation.". Biochem. J.. 328 ( Pt 3) (3): 807–13. 1998. doi:10.1042/bj3280807. PMID 9396724.
- "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.". EMBO J. 17 (10): 2736–47. 1998. doi:10.1093/emboj/17.10.2736. PMID 9582267.
- "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis.". J. Biol. Chem. 273 (23): 14620–5. 1998. doi:10.1074/jbc.273.23.14620. PMID 9603979.
- "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells.". J. Biol. Chem. 273 (27): 16985–92. 1998. doi:10.1074/jbc.273.27.16985. PMID 9642262.
- "Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines.". Cancer Res. 58 (14): 3116–31. 1998. PMID 9679980.
- "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators.". J. Biol. Chem. 274 (2): 781–6. 1999. doi:10.1074/jbc.274.2.781. PMID 9873016.
- "Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants.". Oncogene 18 (32): 4546–53. 1999. doi:10.1038/sj.onc.1202843. PMID 10467399.
- "A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity.". J. Cell Biol. 146 (5): 929–40. 1999. doi:10.1083/jcb.146.5.929. PMID 10477749.
- "The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome.". J. Biol. Chem. 275 (7): 4613–7. 2000. doi:10.1074/jbc.275.7.4613. PMID 10671488.
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