Biology:DAPK2
 Generic protein structure example |
Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.[1][2]
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites.[2] The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.[3]
References
- ↑ "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene 18 (23): 3471–80. Jun 1999. doi:10.1038/sj.onc.1202701. PMID 10376525.
- ↑ 2.0 2.1 "Entrez Gene: DAPK2 death-associated protein kinase 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23604.
- ↑ Shoval, Yishay; Berissi, Hanna; Kimchi, Adi; Pietrokovski, Shmuel (2011). "New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform". PLOS ONE 6 (2): e17344. doi:10.1371/journal.pone.0017344. PMID 21408167. Bibcode: 2011PLoSO...617344S.
Further reading
- "Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis". Mol. Cell. Biol. 20 (3): 1044–54. 2000. doi:10.1128/MCB.20.3.1044-1054.2000. PMID 10629061.
- "Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding". EMBO J. 20 (5): 1099–113. 2001. doi:10.1093/emboj/20.5.1099. PMID 11230133.
- "High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients". Clin. Cancer Res. 8 (2): 433–7. 2002. PMID 11839660.
- "Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients". Clin. Cancer Res. 8 (2): 464–70. 2002. PMID 11839665.
- "DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death". J. Cell Biol. 157 (3): 455–68. 2002. doi:10.1083/jcb.200109094. PMID 11980920.
- "DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers". Br. J. Cancer 86 (11): 1817–23. 2002. doi:10.1038/sj.bjc.6600319. PMID 12087472.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B.
- "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. 2006. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- "The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells". J. Leukoc. Biol. 81 (6): 1599–608. 2007. doi:10.1189/jlb.0606400. PMID 17347302.
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