Chemistry:SNAP-7941
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Short description: Chemical compound
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| ChEMBL | |
| Chemical and physical data | |
| Formula | C33H41F2N5O6 |
| Molar mass | 641.704 g·mol−1 |
| 3D model (JSmol) | |
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SNAP-7941 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In initial animal studies it had promising anxiolytic, antidepressant and anorectic effects,[1][2] but subsequent trial results were disappointing,[3] and the main significance of SNAP-7941 is as the lead compound from which more potent and selective antagonists such as SNAP-94847 were developed,[4][5] although it continues to be used for research into the function of the MCH1 receptor.[6][7]
References
- ↑ "Antidepressant, anxiolytic and anorectic effects of a melanin-concentrating hormone-1 receptor antagonist". Nature Medicine 8 (8): 825–30. August 2002. doi:10.1038/nm741. PMID 12118247.
- ↑ Doggrell SA (June 2003). "Does the melanin-concentrating hormone antagonist SNAP-7941 deserve 3As?". Expert Opinion on Investigational Drugs 12 (6): 1035–8. doi:10.1517/13543784.12.6.1035. PMID 12783607.
- ↑ "Lack of efficacy of melanin-concentrating hormone-1 receptor antagonists in models of depression and anxiety". European Journal of Pharmacology 540 (1–3): 115–20. July 2006. doi:10.1016/j.ejphar.2006.04.043. PMID 16765941.
- ↑ "Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit". Journal of Medicinal Chemistry 50 (16): 3870–82. August 2007. doi:10.1021/jm060381c. PMID 17668921.
- ↑ "Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits". Journal of Medicinal Chemistry 50 (16): 3883–90. August 2007. doi:10.1021/jm060383x. PMID 17668922.
- ↑ "The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats". The International Journal of Neuropsychopharmacology 11 (8): 1105–22. December 2008. doi:10.1017/S1461145708008894. PMID 18466669.
- ↑ "The role of melanin-concentrating hormone-1 receptors in the voiding reflex in rats". The Journal of Pharmacology and Experimental Therapeutics 328 (1): 165–73. January 2009. doi:10.1124/jpet.108.143495. PMID 18849359.
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