Chemistry:SNAP-94847
From HandWiki
Short description: Chemical compound
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| Formula | C29H32F2N2O2 |
| Molar mass | 478.572 g·mol−1 |
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SNAP-94847 is a drug used in scientific research, which is a selective, non-peptide antagonist at the melanin concentrating hormone receptor MCH1. In animal studies it has been shown to produce both anxiolytic and antidepressant effects,[1][2] and also reduces food consumption suggesting a possible anorectic effect.[3]
References
- ↑ "Efficacy of the MCHR1 antagonist N-[3-(1-{[4-(3,4-difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in mouse models of anxiety and depression following acute and chronic administration is independent of hippocampal neurogenesis". The Journal of Pharmacology and Experimental Therapeutics 321 (1): 237–48. April 2007. doi:10.1124/jpet.106.109678. PMID 17237257.
- ↑ "The effects of stressful stimuli and hypothalamic-pituitary-adrenal axis activation are reversed by the melanin-concentrating hormone 1 receptor antagonist SNAP 94847 in rodents". Behavioural Brain Research 197 (2): 284–91. February 2009. doi:10.1016/j.bbr.2008.08.026. PMID 18793675.
- ↑ "Effects of the MCH1 receptor antagonist SNAP 94847 on high-fat food-reinforced operant responding and reinstatement of food seeking in rats". Psychopharmacology 205 (1): 129–40. July 2009. doi:10.1007/s00213-009-1523-6. PMID 19340414.
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