Chemistry:CDPPB
From HandWiki
Short description: Chemical compound
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| Formula | C23H18N4O |
| Molar mass | 366.424 g·mol−1 |
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CDPPB is a drug used in scientific research which acts as a positive allosteric modulator selective for the metabotropic glutamate receptor subtype mGluR5.[1][2][3] It has antipsychotic effects in animal models,[4] and mGluR5 modulators are under investigation as potential drugs for the treatment of schizophrenia,[5] as well as other applications.[6][7]
References
- ↑ "Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo". Journal of Medicinal Chemistry 47 (24): 5825–8. November 2004. doi:10.1021/jm049400d. PMID 15537338.
- ↑ "Substituent effects of N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides on positive allosteric modulation of the metabotropic glutamate-5 receptor in rat cortical astrocytes". Journal of Medicinal Chemistry 49 (11): 3332–44. June 2006. doi:10.1021/jm051252j. PMID 16722652.
- ↑ "Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses". Molecular Pharmacology 71 (5): 1389–98. May 2007. doi:10.1124/mol.106.032425. PMID 17303702.
- ↑ "A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models". The Journal of Pharmacology and Experimental Therapeutics 313 (1): 199–206. April 2005. doi:10.1124/jpet.104.079244. PMID 15608073.
- ↑ "Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia". Current Topics in Medicinal Chemistry 6 (8): 771–85. 2006. doi:10.2174/156802606777057599. PMID 16719816.
- ↑ "Positive allosteric modulation of metabotropic glutamate 5 (mGlu5) receptors reverses N-Methyl-D-aspartate antagonist-induced alteration of neuronal firing in prefrontal cortex". Biological Psychiatry 62 (7): 739–46. October 2007. doi:10.1016/j.biopsych.2006.12.003. PMID 17511968.
- ↑ "Positive allosteric modulation of mGluR5 receptors facilitates extinction of a cocaine contextual memory". Biological Psychiatry 65 (8): 717–20. April 2009. doi:10.1016/j.biopsych.2008.11.001. PMID 19100966.
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