Biology:BPS domain
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Revision as of 13:59, 29 July 2021 by imported>AstroAI (fixing)
| BPS | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of the grb14 bps region in complex with the insulin receptor tyrosine kinase | |||||||||
| Identifiers | |||||||||
| Symbol | BPS | ||||||||
| Pfam | PF08947 | ||||||||
| InterPro | IPR015042 | ||||||||
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In molecular biology, the BPS domain (Between PH and SH2) domain is a protein domain of approximately 45 amino acids found in the adaptor proteins Grb7/|Grb10/Grb14. It mediates inhibition of the tyrosine kinase domain of the insulin receptor by binding of the N-terminal portion of the BPS domain to the substrate peptide groove of the kinase, acting as a pseudosubstrate inhibitor. It is composed of two beta strands and a C-terminal helix.[1]
References
- ↑ "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14". Mol. Cell 20 (2): 325–33. October 2005. doi:10.1016/j.molcel.2005.09.001. PMID 16246733.
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