Chemistry:Lu AA-33810

Short description: Chemical compound

Lu AA-33810

Clinical data
Other names	Lu AA-33810
ATC code	None
Identifiers
IUPAC name N-[(trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl)methyl]methanesulfonamide
PubChem CID	22254068
ChemSpider	21223462
ChEMBL	ChEMBL1836317
Chemical and physical data
Formula	C19H25N3O2S3
Molar mass	423.61 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=S(C)(=O)NCC3CCC(CC3)Nc4sc2CCSc1ccccc1-c2n4
InChI InChI=1S/C19H25N3O2S3/c1-27(23,24)20-12-13-6-8-14(9-7-13)21-19-22-18-15-4-2-3-5-16(15)25-11-10-17(18)26-19/h2-5,13-14,20H,6-12H2,1H3,(H,21,22) Key:UWSBTSAJZMIHBL-UHFFFAOYSA-N
(verify)

Lu AA-33810 is a drug developed by Lundbeck, which acts as a potent and highly selective antagonist for the Neuropeptide Y receptor Y₅, with a Ki of 1.5nM and around 3300x selectivity over the related Y₁, Y₂ and Y₄ receptors. In animal studies it produced anorectic, antidepressant and anxiolytic effects, and further research is now being conducted into its possible medical application in the treatment of eating disorders.