Biology:WPP domain
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| WPP domain | |||||||||
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| Identifiers | |||||||||
| Symbol | WPP | ||||||||
| Pfam | PF13943 | ||||||||
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The WPP domain is a protein domain thought to be exclusively found in plants, first identified in 2000.[1] The domain is about 90 amino acid residues long.
The domain is known to direct RanGAP to the nuclear envelope.[2] Non-RanGAP nuclear envelope proteins are also known to encode WPP domains, such as MFP1 attachment factor 1 (MAF1),[1] WPP1[3] and WPP2.[3]
The WPP stands for a tryptophan-proline-proline motif that is highly conserved in the domain.[1] Either deletion of the WPP domain or mutation of both the namesake tryptophan and first proline residues into alanine in the Arabidopsis thaliana protein RanGAP1 leads to mis-targeting in the majority of cells.[2]
A multiple sequence alignment of proteins containing a WPP domain showing the conserved WPP sequence motif to the left.
References
- ↑ 1.0 1.1 1.2 Meier I (December 2000). "A novel link between ran signal transduction and nuclear envelope proteins in plants". Plant Physiology 124 (4): 1507–10. doi:10.1104/pp.124.4.1507. PMID 11115866.
- ↑ 2.0 2.1 "A domain unique to plant RanGAP is responsible for its targeting to the plant nuclear rim". Proceedings of the National Academy of Sciences of the United States of America 98 (26): 15377–82. December 2001. doi:10.1073/pnas.261459698. PMID 11752475.
- ↑ 3.0 3.1 "Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division". The Plant Cell 16 (12): 3260–73. December 2004. doi:10.1105/tpc.104.026740. PMID 15548735.
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