Medicine:HIV Cohorts Data Exchange Protocol

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The HIV Cohorts Data Exchange Protocol (HICDEP) is a protocol that allows for simple sharing of data from HIV cohorts by providing a standard format for datasets. It is used by several major HIV Cohort Collaborations such as CASCADE, COHERE,[1][2] EuroSIDA,[3] PENTA, EPPICC[4] ART-CC[5] and D:A:D.[6] Its first version was presented at the 7th International Workshop on HIV Observational Databases on March 29–30, 2003, Fiuggi, Italy,[7] and a summary was published in Antiviral Therapy.[8] The specification currently consists of 27 tables in a relational structure[9] which cover most medical aspects of HIV patient histories used in clinical research, including pediatric aspects.

Despite the tremendous success of Anti-retroviral treatment there remain many questions about HIV and its effects on the individual. Since many events occur infrequently or relate to a small group of patients, it is necessary to pull information from different cohorts. The standardized format given by HICDEP not only simplifies merging data from multiple HIV cohorts, but also provides a set of quality control checks. Prior to HICDEP, each collaboration used proprietary protocols for data exchange requiring substantial data-management efforts, which are potentially error-prone.

Where possible, HICDEP relies on already published coding systems such as the WHO's Anatomical Therapeutic Chemical (ATC) codes[10] or the International Classification of Diseases (ICD-10) codes.[11]

Special emphasis was given to the different ways resistance data are collected and reported in research settings and routine clinical practice: for genotypic analyses nucleotide or amino acid sequences (level 1), amino acid changes (mutations) from a reference strain (level 2) and drug-specific resistance scores (level 3) were considered.[8]

Since January 2011, the format is being developed further in the scope of the FP7 EuroCoord project.[12] On September 4, 2019 the current version 1.110 was released.[13] For the development of the HICDEP standard, there was set up a discussion forum[14] on the project website. In addition, to learn more about HICDEP and how it works, there is an e-learning module available on the EuroCoord training page.[15]

See also

Sources

  1. ↑ "Standard Operating Procedure for data transfer". COHERE. Archived from the original on 21 July 2011. https://web.archive.org/web/20110721022611/http://etudes.isped.u-bordeaux2.fr/cohere/TELECHARGEMENTS/COHERE_SOP_for_PLATO_II_1st_merger.pdf. Retrieved 4 February 2011. 
  2. ↑ Audelin, Anne; Castagna, Antonella; Costagliola, Dominique; Cozzi-Lepri, Alessandro; De Luca, Andrea; De Wit, Stephane; De Wolf, Frank; Dorrucci, Maria et al. (2013). "Predictors of CD4+ T-Cell Counts of HIV Type 1–Infected Persons After Virologic Failure of All 3 Original Antiretroviral Drug Classes". The Journal of Infectious Diseases 207 (5): 759–767. doi:10.1093/infdis/jis752. PMID 23225900. 
  3. ↑ Podlekareva, Daria N.; Reekie, Joanne; Mocroft, Amanda; Losso, Marcelo; Rakhmanova, Aza G.; Bakowska, Elzbieta; Karpov, Igor A.; Lazarus, Jeffrey V. et al. (2012). "Benchmarking HIV health care: from individual patient care to health care evaluation. An example from the EuroSIDA study". BMC Infectious Diseases 12: 229. doi:10.1186/1471-2334-12-229. PMID 23009317. 
  4. ↑ Judd, Ali; Duong, Trinh; Galli, Luisa; Goetghebuer, Tessa; Ene, Luminita; Julian, Antoni Noguera; Amador, Jose Tomas Ramos; Pimenta, Jeanne Marie et al. (2014). "Post-licensing safety of fosamprenavir in HIV-infected children in Europe". Pharmacoepidemiology and Drug Safety 23 (3): 321–325. doi:10.1002/pds.3543. PMID 24741696. 
  5. ↑ "Cohort Profile: Antiretroviral Therapy Cohort Collaboration (ART-CC)". http://ije.oxfordjournals.org/content/43/3/691.full.pdf+html. Retrieved 2 March 2015. 
  6. ↑ "Standard Operating Procedures for the 10th merger". D:A:D. Archived from the original on 19 March 2012. https://web.archive.org/web/20120319174441/http://www.cphiv.dk/portals/0/files/DAD%2010th%20merger%20SOP%20version%202.0.pdf. Retrieved 15 August 2011. 
  7. ↑ "About HICDEP". https://hicdep.org/Wiki/About-HICDEP. Retrieved 20 May 2020. 
  8. ↑ 8.0 8.1 Kjær, Jesper; Ledergerber, Bruno (2004). "HIV cohort collaborations: proposal for harmonization of data exchange". Antiviral Therapy. http://www.intmedpress.com/serveFile.cfm?sUID=43006633-9858-42f9-bae2-26491554a144. Retrieved 4 February 2011. 
  9. ↑ "Table Overview - Release 1.8". http://www.hicdep.org/wiki/Hicdep_1.80#Diagram. Retrieved 3 March 2015. 
  10. ↑ "HICDEP 1.50 ATC codes". http://www.hicdep.org/wiki/Hicdep_1.50#ATCcodes. Retrieved 13 September 2011. 
  11. ↑ "HICDEP 1.50 ICD-10codes". http://www.hicdep.org/wiki/Hicdep_1.50#ICD-10codes. Retrieved 13 September 2011. 
  12. ↑ "Work Package 4: Data management". http://www.eurocoord.net/workpackages.aspx#wp4. Retrieved 13 September 2011. 
  13. ↑ "Wiki". https://hicdep.org/. 
  14. ↑ "HICDEP discussion forum". http://www.hicdep.org/discussion. Retrieved 2 March 2015. 
  15. ↑ "HICDEP e-learning module". http://www.eurocoord.net/training/training_modules.htm. Retrieved 2 March 2015. 

External links




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