Chemistry:Superagonist

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Efficacy spectrum of receptor ligands.

In the field of pharmacology, a superagonist is a type of agonist that is capable of producing a maximal response greater than the endogenous agonist for the target receptor, and thus has an efficacy of more than 100%.[1][2] For example, goserelin is a superagonist of the gonadotropin-releasing hormone receptor.

See also

References

  1. ↑ "Discovery of non-zwitterionic GABAA receptor full agonists and a superagonist". Bioorg. Med. Chem. Lett. 12 (15): 1985–8. August 2002. doi:10.1016/S0960-894X(02)00299-8. PMID 12113824. 
  2. ↑ "Heterozygous α2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12471–6. September 2002. doi:10.1073/pnas.122368499. PMID 12205290. Bibcode: 2002PNAS...9912471T. 




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