Chemistry:Functional analog
From HandWiki
In chemistry and pharmacology, functional analogs are chemical compounds that have similar physical, chemical, biochemical, or pharmacological properties. Functional analogs are not necessarily structural analogs with a similar chemical structure.[1] An example of pharmacological functional analogs are morphine, heroin and fentanyl, which have the same mechanism of action, but fentanyl is structurally quite different from the other two with significant variance in dosage.[2]
See also
- Federal Analogue Act
References
- ↑ Martin, Yvonne C.; Kofron, James L.; Traphagen, Linda M. (2002). "Do Structurally Similar Molecules Have Similar Biological Activity?". Journal of Medicinal Chemistry 45 (19): 4350–8. doi:10.1021/jm020155c. PMID 12213076.
- ↑ Mutschler, Ernst; Schäfer-Korting, Monika (2001) (in German). Arzneimittelwirkungen (8 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. pp. 214f, 286. ISBN 3-8047-1763-2.
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