Biology:ARG1 (gene)

Generic protein structure example

The human ARG1 gene encodes the protein arginase.

Function

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.

External links

• Human ARG1 genome location and ARG1 gene details page in the UCSC Genome Browser.

Further reading

• "Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease". JAMA 294 (1): 81–90. July 2005. doi:10.1001/jama.294.1.81. PMID 15998894. 
• "Arginase-flotillin interaction brings arginase to red blood cell membrane". FEBS Letters 580 (28–29): 6561–4. December 2006. doi:10.1016/j.febslet.2006.11.003. PMID 17113085. 
• "Recent advances in arginine metabolism: roles and regulation of the arginases". British Journal of Pharmacology 157 (6): 922–30. July 2009. doi:10.1111/j.1476-5381.2009.00278.x. PMID 19508396. 
• "Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation". Journal of Leukocyte Biology 89 (5): 721–7. May 2011. doi:10.1189/jlb.1109737. PMID 21330347. 
• "RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression". Nucleic Acids Research 15 (17): 7155–74. September 1987. doi:10.1093/nar/15.17.7155. PMID 3658675. 
• "IL-8 induces exocytosis of arginase 1 by neutrophil polymorphonuclears in nonsmall cell lung cancer". International Journal of Cancer 125 (4): 887–93. August 2009. doi:10.1002/ijc.24448. PMID 19431148. 
• "Genetic variations in nitric oxide synthase and arginase influence exhaled nitric oxide levels in children". Allergy 66 (3): 412–9. March 2011. doi:10.1111/j.1398-9995.2010.02492.x. PMID 21039601. 
• Creighton, Chad, ed (August 2010). "Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer". PLOS ONE 5 (8): e12107. doi:10.1371/journal.pone.0012107. PMID 20711410. 
• "Identification of arginase in human placental villi". Placenta 28 (2–3): 133–8. 2007. doi:10.1016/j.placenta.2006.03.015. PMID 16720041. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.