Biology:NAD(P)H dehydrogenase, quinone 2

NAD(P)H dehydrogenase, quinone 2, also known as QR2, is a protein that in humans is encoded by the NQO2 gene. It is a phase II detoxification enzyme which can carry out two or four electron reductions. Its mechanism of reduction is via a covalently bound zinc ion and a cocrystalized FAD. NQO2 contains two chains homologous in AA sequence but 7% different in structure. As a result, NQO2 contains two similar yet unique active sites. An important function of NQO2 is its activation on NRH. NQO2 can be inhibited by resveratrol.^[1]

References

↑ "Entrez Gene: NQO2 NAD(P)H dehydrogenase, quinone 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4835.

"Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P)H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6.". Biochemistry 29 (7): 1899–906. 1990. doi:10.1021/bi00459a034. PMID 1691923.
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"Unexpected genetic and structural relationships of a long-forgotten flavoenzyme to NAD(P)H:quinone reductase (DT-diaphorase)". Proc. Natl. Acad. Sci. U.S.A. 94 (5): 1669–74. 1997. doi:10.1073/pnas.94.5.1669. PMID 9050836.
"Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase.". Arch. Biochem. Biophys. 347 (2): 221–8. 1997. doi:10.1006/abbi.1997.0344. PMID 9367528.
"Crystal structure of human quinone reductase type 2, a metalloflavoprotein.". Biochemistry 38 (31): 9881–6. 1999. doi:10.1021/bi990799v. PMID 10433694.
"Localization of human NQO1 gene to chromosome 16q22 and NQO2-6p25 and associated polymorphisms.". Pharmacogenetics 9 (3): 413–8. 1999. doi:10.1097/00008571-199906000-00020. PMID 10471077.
"An association between idiopathic Parkinson's disease and polymorphisms of phase II detoxification enzymes: glutathione S-transferase M1 and quinone oxidoreductase 1 and 2.". Biochem. Biophys. Res. Commun. 288 (4): 887–92. 2001. doi:10.1006/bbrc.2001.5868. PMID 11688992.
"Differential gene expression of NAD(P)H:quinone oxidoreductase and NRH:quinone oxidoreductase in human hepatocellular and biliary tissue.". Mol. Pharmacol. 61 (2): 320–5. 2002. doi:10.1124/mol.61.2.320. PMID 11809856.
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
"Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptoms.". Alcohol. Clin. Exp. Res. 27 (8 Suppl): 68S–71S. 2004. doi:10.1097/01.ALC.0000078616.63296.41. PMID 12960511.
"NQO2 gene is associated with clozapine-induced agranulocytosis.". Tissue Antigens 62 (6): 483–91. 2004. doi:10.1046/j.1399-0039.2003.00133.x. PMID 14617031.
"A possible association between an insertion/deletion polymorphism of the NQO2 gene and schizophrenia.". Psychiatr. Genet. 13 (4): 205–9. 2005. doi:10.1097/01.ypg.0000071601.59979.47. PMID 14639047.
"Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
"Kinetic mechanism of quinone oxidoreductase 2 and its inhibition by the antimalarial quinolines.". Biochemistry 43 (15): 4538–47. 2004. doi:10.1021/bi035923w. PMID 15078100.
"Crystal structure of quinone reductase 2 in complex with resveratrol.". Biochemistry 43 (36): 11417–26. 2004. doi:10.1021/bi049162o. PMID 15350128.
"Sp3 repression of polymorphic human NRH:quinone oxidoreductase 2 gene promoter.". Free Radic. Biol. Med. 37 (8): 1231–43. 2005. doi:10.1016/j.freeradbiomed.2004.06.042. PMID 15451063.
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
"Inhibition of melanoma cell proliferation by resveratrol is correlated with upregulation of quinone reductase 2 and p53.". Biochem. Biophys. Res. Commun. 334 (1): 223–30. 2005. doi:10.1016/j.bbrc.2005.06.073. PMID 15993843.
"Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954.". Biochem. Biophys. Res. Commun. 336 (1): 332–8. 2005. doi:10.1016/j.bbrc.2005.08.081. PMID 16129418.
"Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514.

External links

Overview of all the structural information available in the PDB for UniProt: P16083 (Ribosyldihydronicotinamide dehydrogenase [quinone]) at the PDBe-KB.