Biology:PIK3R3
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Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.[1][2]
Interactions
PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor,[3] IRS1[3][4] and Retinoblastoma protein.[5]
References
- ↑ "Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor". Gene 209 (1–2): 175–83. May 1998. doi:10.1016/S0378-1119(98)00045-6. PMID 9524259.
- ↑ "Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8503.
- ↑ 3.0 3.1 Mothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. ISSN 0888-8809. PMID 9415396.
- ↑ Xia, X; Serrero G (Aug 1999). "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. ISSN 0264-6021. PMID 10417350.
- ↑ Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. ISSN 0270-7306. PMID 12588990.
Further reading
- "The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase". Mol. Cell. Biol. 15 (8): 4453–65. 1995. doi:10.1128/MCB.15.8.4453. PMID 7542745.
- "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474.
- "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22". Eur. J. Immunol. 26 (6): 1246–52. 1996. doi:10.1002/eji.1830260610. PMID 8647200.
- "Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK". Oncogene 14 (19): 2273–82. 1997. doi:10.1038/sj.onc.1201071. PMID 9178903.
- "Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins". Mol. Endocrinol. 11 (13): 1911–23. 1998. doi:10.1210/mend.11.13.0029. PMID 9415396.
- "Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation". Biochem. J. 341 (3): 831–7. 1999. doi:10.1042/0264-6021:3410831. PMID 10417350.
- "Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations". FEBS Lett. 490 (1–2): 32–8. 2001. doi:10.1016/S0014-5793(01)02132-9. PMID 11172806.
- "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. 2003. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest". Mol. Cell. Biol. 23 (5): 1717–25. 2003. doi:10.1128/MCB.23.5.1717-1725.2003. PMID 12588990.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma". Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3466–71. 2007. doi:10.1073/pnas.0611271104. PMID 17360667. Bibcode: 2007PNAS..104.3466S.
- "SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma". J. Lipid Res. 48 (7): 1628–36. 2007. doi:10.1194/jlr.M700136-JLR200. PMID 17452746.
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