Biology:ERRFI1
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 Generic protein structure example |
ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.[1][2][3][4][5]
MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM][5]
Interactions
ERRFI1 has been shown to interact with Stratifin[6] and CDC42.[1]
References
- ↑ 1.0 1.1 "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". The Journal of Biological Chemistry 275 (23): 17838–47. June 2000. doi:10.1074/jbc.M909735199. PMID 10749885.
- ↑ "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Research 17 (16): 6651–67. August 1989. doi:10.1093/nar/17.16.6651. PMID 2780291.
- ↑ "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene 21 (42): 6530–9. September 2002. doi:10.1038/sj.onc.1205823. PMID 12226756.
- ↑ "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Molecular and Cellular Biology 20 (20): 7735–50. October 2000. doi:10.1128/MCB.20.20.7735-7750.2000. PMID 11003669.
- ↑ 5.0 5.1 "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54206.
- ↑ "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics 4 (6): 785–95. June 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Further reading
- "Mig-6, signal transduction, stress response and cancer". Cell Cycle 6 (5): 507–13. March 2007. doi:10.4161/cc.6.5.3928. PMID 17351343.
- "Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation". Experimental Cell Research 219 (2): 527–35. August 1995. doi:10.1006/excr.1995.1261. PMID 7641805.
- "Mig-6 is a negative regulator of the epidermal growth factor receptor signal". Biological Chemistry 382 (12): 1649–62. December 2001. doi:10.1515/BC.2001.200. PMID 11843178.
- "A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6". Cancer Research 62 (20): 5668–71. October 2002. PMID 12384522.
- "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia". FEBS Letters 530 (1–3): 186–90. October 2002. doi:10.1016/S0014-5793(02)03475-0. PMID 12387890.
- "Feedback inhibition by RALT controls signal output by the ErbB network". Oncogene 22 (27): 4221–34. July 2003. doi:10.1038/sj.onc.1206516. PMID 12833145.
- "Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function". The Journal of Biological Chemistry 280 (4): 2924–33. January 2005. doi:10.1074/jbc.M408907200. PMID 15556944.
- "Modulation of Elk-dependent-transcription by Gene33". Journal of Cellular Biochemistry 94 (6): 1190–8. April 2005. doi:10.1002/jcb.20370. PMID 15696545.
- "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics 4 (6): 785–95. June 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- "Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin". Oncogene 24 (28): 4540–8. June 2005. doi:10.1038/sj.onc.1208658. PMID 15856022.
- "Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype". EMBO Reports 6 (8): 755–61. August 2005. doi:10.1038/sj.embor.7400458. PMID 16007071.
- "Evidence that MIG-6 is a tumor-suppressor gene". Oncogene 26 (2): 269–76. January 2007. doi:10.1038/sj.onc.1209790. PMID 16819504.
External links
- Overview of all the structural information available in the PDB for UniProt: Q9UJM3 (ERBB receptor feedback inhibitor 1) at the PDBe-KB.
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