Biology:Stratifin
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans.[1][2] The protein is named for its presence in stratified epithelial cells.[1]
Interactions
Stratifin has been shown to interact with PLK4,[3] ERRFI1,[4] MARK3,[3][4] JUB[4] and YWHAG.[4]
References
- ↑ 1.0 1.1 "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway". Journal of Molecular Biology 231 (4): 982–98. June 1993. doi:10.1006/jmbi.1993.1346. PMID 8515476.
- ↑ "Entrez Gene: SFN stratifin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2810.
- ↑ 3.0 3.1 "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ 4.0 4.1 4.2 4.3 "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics 4 (6): 785–95. June 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Further reading
- "Extracellular 14-3-3sigma protein: a potential mediator of epithelial-mesenchymal interactions". The Journal of Investigative Dermatology 124 (1): ix-x. January 2005. doi:10.1111/j.0022-202X.2004.23534.x. PMID 15654940.
- "14-3-3 proteins--an update". Cell Research 15 (4): 228–36. April 2005. doi:10.1038/sj.cr.7290291. PMID 15857577.
- "The role of epigenetic inactivation of 14-3-3sigma in human cancer". Cell Research 15 (4): 237–46. April 2005. doi:10.1038/sj.cr.7290292. PMID 15857578.
- "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". Electrophoresis 13 (12): 960–9. December 1992. doi:10.1002/elps.11501301199. PMID 1286667.
- "Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells". Cell Growth & Differentiation 3 (8): 507–13. August 1992. PMID 1390337.
- "14-3-3sigma is a p53-regulated inhibitor of G2/M progression". Molecular Cell 1 (1): 3–11. December 1997. doi:10.1016/S1097-2765(00)80002-7. PMID 9659898.
- "14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage". Nature 401 (6753): 616–20. October 1999. doi:10.1038/44188. PMID 10524633. Bibcode: 1999Natur.401..616C.
- "Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression". The Journal of Biological Chemistry 275 (30): 23106–12. July 2000. doi:10.1074/jbc.M905616199. PMID 10767298.
- "The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax". The Journal of Biological Chemistry 276 (48): 45201–6. November 2001. doi:10.1074/jbc.M106427200. PMID 11574543.
- "Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms". The Journal of Biological Chemistry 277 (20): 18029–36. May 2002. doi:10.1074/jbc.M110465200. PMID 11886850.
- "Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways". Neoplasia 4 (2): 171–80. 2002. doi:10.1038/sj.neo.7900219. PMID 11896572.
- "Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression". Proceedings of the National Academy of Sciences of the United States of America 99 (7): 4373–8. April 2002. doi:10.1073/pnas.072624299. PMID 11917136. Bibcode: 2002PNAS...99.4373K.
- "Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth". Nature 417 (6891): 871–5. June 2002. doi:10.1038/nature00826. PMID 12075357. Bibcode: 2002Natur.417..871U.
- "14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s)". Cancer Research 62 (22): 6475–80. November 2002. PMID 12438239.
- "The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells". Cancer Epidemiology, Biomarkers & Prevention 12 (2): 165–9. February 2003. PMID 12582028.
- "Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway". The Journal of Biological Chemistry 278 (28): 25651–6. July 2003. doi:10.1074/jbc.M302818200. PMID 12730237.
- "Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage". Pathology International 53 (6): 353–60. June 2003. doi:10.1046/j.1440-1827.2003.01481.x. PMID 12787309.
- "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437". The Journal of Biological Chemistry 278 (35): 33422–35. August 2003. doi:10.1074/jbc.M303173200. PMID 12816952.
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