Biology:ERRFI1

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.[1][2][3][4][5]

MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM][5]

Interactions

ERRFI1 has been shown to interact with Stratifin[6] and CDC42.[1]

References

  1. 1.0 1.1 "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". The Journal of Biological Chemistry 275 (23): 17838–47. June 2000. doi:10.1074/jbc.M909735199. PMID 10749885. 
  2. "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Research 17 (16): 6651–67. August 1989. doi:10.1093/nar/17.16.6651. PMID 2780291. 
  3. "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene 21 (42): 6530–9. September 2002. doi:10.1038/sj.onc.1205823. PMID 12226756. 
  4. "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Molecular and Cellular Biology 20 (20): 7735–50. October 2000. doi:10.1128/MCB.20.20.7735-7750.2000. PMID 11003669. 
  5. 5.0 5.1 "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54206. 
  6. "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics 4 (6): 785–95. June 2005. doi:10.1074/mcp.M500021-MCP200. PMID 15778465. 

Further reading

External links

  • Overview of all the structural information available in the PDB for UniProt: Q9UJM3 (ERBB receptor feedback inhibitor 1) at the PDBe-KB.