Biology:COG7

Generic protein structure example

Conserved oligomeric Golgi complex subunit 7 is a protein that in humans is encoded by the COG7 gene.

Multiprotein complexes are key determinants of Golgi apparatus structure and its capacity for intracellular transport and glycoprotein modification. Several complexes have been identified, including the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex, which includes COG7 (Ungar et al., 2002).[supplied by OMIM]

Interactions

COG7 has been shown to interact with COG4 and COG5.

Further reading

• "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. 1996. doi:10.1006/abio.1996.0138. PMID 8619474. 
• "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. 1997. doi:10.1101/gr.7.4.353. PMID 9110174. 
• "Sec34 is implicated in traffic from the endoplasmic reticulum to the Golgi and exists in a complex with GTC-90 and ldlBp.". J. Biol. Chem. 277 (24): 21955–61. 2002. doi:10.1074/jbc.M202326200. PMID 11929878. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. 2003. doi:10.1101/gr.1293003. PMID 12975309. 
• "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
• "The binary interacting network of the conserved oligomeric Golgi tethering complex.". J. Biol. Chem. 279 (23): 24640–8. 2004. doi:10.1074/jbc.M400662200. PMID 15047703. 
• "Mutation of the COG complex subunit gene COG7 causes a lethal congenital disorder.". Nat. Med. 10 (5): 518–23. 2004. doi:10.1038/nm1041. PMID 15107842. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Genetic analysis of the subunit organization and function of the conserved oligomeric golgi (COG) complex: studies of COG5- and COG7-deficient mammalian cells.". J. Biol. Chem. 280 (38): 32736–45. 2005. doi:10.1074/jbc.M505558200. PMID 16051600. 
• "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "COG-7-deficient Human Fibroblasts Exhibit Altered Recycling of Golgi Proteins.". Mol. Biol. Cell 17 (5): 2312–21. 2006. doi:10.1091/mbc.E05-08-0822. PMID 16510524. 
• "A common mutation in the COG7 gene with a consistent phenotype including microcephaly, adducted thumbs, growth retardation, VSD and episodes of hyperthermia.". Eur. J. Hum. Genet. 15 (6): 638–45. 2007. doi:10.1038/sj.ejhg.5201813. PMID 17356545. 

External links

• GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview
• Human COG7 genome location and COG7 gene details page in the UCSC Genome Browser.