Biology:PADI1
 Generic protein structure example |
Peptidyl arginine deiminase, type I, also known as PADI1, is a protein which in humans is encoded by the PADI1 gene.[1][2]
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: PADI1 peptidyl arginine deiminase, type I". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29943.
- ↑ "cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I". The Biochemical Journal 370 (Pt 1): 167–74. February 2003. doi:10.1042/BJ20020870. PMID 12416996.
Further reading
- "PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease.". BioEssays 25 (11): 1106–18. 2004. doi:10.1002/bies.10357. PMID 14579251.
- "Peptidylarginine deiminases and deimination in biology and pathology: relevance to skin homeostasis.". J. Dermatol. Sci. 44 (2): 63–72. 2006. doi:10.1016/j.jdermsci.2006.07.004. PMID 16973334.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type I". Biochem. J. 370 (Pt 1): 167–74. 2003. doi:10.1042/BJ20020870. PMID 12416996.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6". Gene 330: 19–27. 2004. doi:10.1016/j.gene.2003.12.038. PMID 15087120.
- "Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13". J. Hum. Genet. 49 (7): 387–90. 2004. doi:10.1007/s10038-004-0156-1. PMID 15150696.
- "Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin". J. Invest. Dermatol. 124 (2): 384–93. 2005. doi:10.1111/j.0022-202X.2004.23568.x. PMID 15675958.
- "The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations". Cell. Mol. Life Sci. 62 (17): 1984–95. 2005. doi:10.1007/s00018-005-5196-y. PMID 16091842.
- "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. 2006. doi:10.1038/nature04727. PMID 16710414. Bibcode: 2006Natur.441..315G.
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