Biology:KIAA1279

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A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene.[1] The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator.[2] Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis.[3] Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis,[4] and hence it can be therapeutically used to control Kif15 upregulated cancer cells.

Clinical significance

Defects may be associated with Goldberg–Shprintzen syndrome (OMIM 609460).

Interactions

KIAA1279 has been shown to interact with Retinal G protein coupled receptor[5] and Dipeptidase 1.[5]

References

  1. "Entrez Gene: KIAA1279 KIAA1279". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26128. 
  2. "Role of Kif15 and its novel mitotic partner KBP in K-fiber dynamics and chromosome alignment". PLOS ONE 12 (4): e0174819. 2017-04-26. doi:10.1371/journal.pone.0174819. PMID 28445502. Bibcode2017PLoSO..1274819B. 
  3. "The role of Hklp2 in the stabilization and maintenance of spindle bipolarity". Current Biology 19 (20): 1712–7. November 2009. doi:10.1016/j.cub.2009.09.019. PMID 19818619. 
  4. "Benserazide Perturbs Kif15-kinesin Binding Protein Interaction with Prolonged Metaphase and Defects in Chromosomal Congression: A Study Based on in silico Modeling and Cell Culture". Molecular Informatics 39 (3): minf.201900035. July 2019. doi:10.1002/minf.201900035. PMID 31347789. 
  5. 5.0 5.1 "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode2005Natur.437.1173R. 

Further reading

External links