Biology:KIAA1279
 Generic protein structure example |
KIF1-binding protein, also known as Kinesin binding protein(KBP), is a protein that in humans is encoded by the KIAA1279 gene.[1] The interaction of KBP with Kif15 is necessary for the localization of Kif15 to the microtubule plus-end at the spindle equator.[2] Interaction between Kif15 and KBP is essential for the perfect alignment of chromosomes at the metaphase plate, and any defect in their interaction leads to delay in chromosomal alignment during mitosis.[3] Anything that perturb the interaction of KBP and Kif15 can block the cells at mitosis,[4] and hence it can be therapeutically used to control Kif15 upregulated cancer cells.
Clinical significance
Defects may be associated with Goldberg–Shprintzen syndrome (OMIM 609460).
Interactions
KIAA1279 has been shown to interact with Retinal G protein coupled receptor[5] and Dipeptidase 1.[5]
References
- ↑ "Entrez Gene: KIAA1279 KIAA1279". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26128.
- ↑ "Role of Kif15 and its novel mitotic partner KBP in K-fiber dynamics and chromosome alignment". PLOS ONE 12 (4): e0174819. 2017-04-26. doi:10.1371/journal.pone.0174819. PMID 28445502. Bibcode: 2017PLoSO..1274819B.
- ↑ "The role of Hklp2 in the stabilization and maintenance of spindle bipolarity". Current Biology 19 (20): 1712–7. November 2009. doi:10.1016/j.cub.2009.09.019. PMID 19818619.
- ↑ "Benserazide Perturbs Kif15-kinesin Binding Protein Interaction with Prolonged Metaphase and Defects in Chromosomal Congression: A Study Based on in silico Modeling and Cell Culture". Molecular Informatics 39 (3): minf.201900035. July 2019. doi:10.1002/minf.201900035. PMID 31347789.
- ↑ 5.0 5.1 "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
Further reading
- "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. 2007. doi:10.1038/msb4100134. PMID 17353931.
- "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–14. May 2006. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
- "The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein". BMC Cell Biology 6: 35. October 2005. doi:10.1186/1471-2121-6-35. PMID 16225668.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Homozygous nonsense mutations in KIAA1279 are associated with malformations of the central and enteric nervous systems". American Journal of Human Genetics 77 (1): 120–6. July 2005. doi:10.1086/431244. PMID 15883926.
- "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 6 (5): 337–45. October 1999. doi:10.1093/dnares/6.5.337. PMID 10574462.
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